Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin
about
Organic anion transporter 6 (Slc22a20) specificity and Sertoli cell-specific expression provide new insight on potential endogenous roles.Competitive inhibition of renal tubular secretion of ciprofloxacin and metabolite by probenecidXenobiotic, bile acid, and cholesterol transporters: function and regulation.Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8)Male-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6Antibiotic Treatment of Dogs and Cats during Pregnancy.Is Ciprofloxacin a Substrate of P-glycoprotein?Physiological and molecular characterization of aristolochic acid transport by the kidneyDeletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury.Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity.Linkage of organic anion transporter-1 to metabolic pathways through integrated "omics"-driven network and functional analysis.Intestinal ciprofloxacin efflux: the role of breast cancer resistance protein (ABCG2).Green tea inhibited the elimination of nephro-cardiovascular toxins and deteriorated the renal function in rats with renal failure.The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy VolunteersGrowth hormone treatment of premature ovarian failure in a mouse model via stimulation of the Notch-1 signaling pathway.Regulation of renal organic anion transporter 3 (SLC22A8) expression and function by the integrity of lipid raft domains and their associated cytoskeletonCompetitive inhibition of renal tubular secretion of gemifloxacin by probenecid.Fluoroquinolone disposition: identification of the contribution of renal secretory and reabsorptive drug transporters.Human organic cation transporters 1 (SLC22A1), 2 (SLC22A2), and 3 (SLC22A3) as disposition pathways for fluoroquinolone antimicrobials.Pharmacokinetics of intravenous finafloxacin in healthy volunteers.The drug transporter OAT3 (SLC22A8) regulates endogenous metabolite flow through the gut-liver-kidney axis.Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and SolutesCumulative organic anion transporter-mediated drug-drug interaction potential of multiple components in salvia miltiorrhiza (danshen) preparations.Renal Drug Transporters and Drug Interactions.Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11).Inhibitory Interaction Potential of 22 Antituberculosis Drugs on Organic Anion and Cation Transporters of the SLC22A Family.Active Hydrophilic Components of the Medicinal Herb Salvia miltiorrhiza (Danshen) Potently Inhibit Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8).Interaction of Ethambutol with human organic cation transporters of the SLC22 family indicates potential for drug-drug interactions during antituberculosis therapy.Transport of gemifloxacin, a 4th generation quinolone antibiotic, in the Caco-2 and engineered MDCKII cells, and potential involvement of efflux transporters in the intestinal absorption of the drug.Evaluation of Proposed In Vivo Probe Substrates and Inhibitors for Phenotyping Transporter Activity in Humans.Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3.Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5.In vitro-in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability.Crystalline nephropathy caused by tosufloxacin.Genetic Heterogeneity of SLC22 Family of Transporters in Drug Disposition.
P2860
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P2860
Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Organic anion transporter 3 (o ...... emic exposure to ciprofloxacin
@ast
Organic anion transporter 3 (o ...... emic exposure to ciprofloxacin
@en
type
label
Organic anion transporter 3 (o ...... emic exposure to ciprofloxacin
@ast
Organic anion transporter 3 (o ...... emic exposure to ciprofloxacin
@en
prefLabel
Organic anion transporter 3 (o ...... emic exposure to ciprofloxacin
@ast
Organic anion transporter 3 (o ...... emic exposure to ciprofloxacin
@en
P2860
P356
P1476
Organic anion transporter 3 (o ...... emic exposure to ciprofloxacin
@en
P2093
Adam L Vanwert
P2860
P304
P356
10.1124/MOL.107.042853
P577
2008-04-01T00:00:00Z