Stepwise intraclonal maturation of antibody affinity through somatic hypermutation
about
A surrogate-based approach for post-genomic partner identificationSerological diagnosis of Epstein-Barr virus infection: Problems and solutionsThe structural basis of repertoire shift in an immune response to phosphocholineReshaping Antibody DiversitySomatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution patternM17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in miceMice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normallyImmunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry.Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes.Optimality of mutation and selection in germinal centers.Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-foldFAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigenMolecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosus-related idiotypesProtein evolution on rugged landscapes.Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection.A Public Database of Memory and Naive B-Cell Receptor SequencesDifferent epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response.Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven responseOptimal Sequential Immunization Can Focus Antibody Responses against Diversity Loss and Distraction.Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary responseIn situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cellsAltering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation.Immunopaleontology reveals how affinity enhancement is achieved during affinity maturation of antibodies to influenza virusPol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability.Conformational inactivation induces immunogenicity of the receptor-binding pocket of a bacterial adhesin.Pathogenic anti-DNA antibodies in SLE: idiotypic families and genetic origins.Innate immunity against molecular mimicry: Examining galectin-mediated antimicrobial activity.Affinity maturation of an ERBB2-targeted SPECT imaging peptide by in vivo phage display.HUMORAL IMMUNITY. T cell help controls the speed of the cell cycle in germinal center B cells.Primary humoral antibody response to Coxiella burnetii, the causative agent of Q fever.The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses.The clonogenic precursor cell in multiple myeloma.IgH and L chain variable region gene sequence analyses of twelve synovial tissue-derived B cell lines producing IgA, IgG, and IgM rheumatoid factors structure/function comparisons of antigenic specificity, V gene sequence, and Ig isotype.What limits affinity maturation of antibodies in Xenopus--the rate of somatic mutation or the ability to select mutants?Multi Step Selection in Ig H Chains is Initially Focused on CDR3 and Then on Other CDR Regions.In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance.Integrating B cell lineage information into statistical tests for detecting selection in Ig sequencesThe mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales.
P2860
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P2860
Stepwise intraclonal maturation of antibody affinity through somatic hypermutation
description
1988 nî lūn-bûn
@nan
1988 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
name
Stepwise intraclonal maturation of antibody affinity through somatic hypermutation
@ast
Stepwise intraclonal maturation of antibody affinity through somatic hypermutation
@en
type
label
Stepwise intraclonal maturation of antibody affinity through somatic hypermutation
@ast
Stepwise intraclonal maturation of antibody affinity through somatic hypermutation
@en
prefLabel
Stepwise intraclonal maturation of antibody affinity through somatic hypermutation
@ast
Stepwise intraclonal maturation of antibody affinity through somatic hypermutation
@en
P2860
P356
P1476
Stepwise intraclonal maturation of antibody affinity through somatic hypermutation
@en
P2093
P2860
P304
P356
10.1073/PNAS.85.21.8206
P407
P577
1988-11-01T00:00:00Z