Nuclear aggregation of polyglutamine-expanded ataxin-3: fragments escape the cytoplasmic quality control.
about
Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila.SUMO-1 modification on K166 of polyQ-expanded ataxin-3 strengthens its stability and increases its cytotoxicity.Toward understanding Machado-Joseph diseaseAggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: implication in a loss-of-function pathology.Ataxin-3 protein and RNA toxicity in spinocerebellar ataxia type 3: current insights and emerging therapeutic strategies.Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease.A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.Altered expression of carbonic anhydrase-related protein XI in neuronal cells expressing mutant ataxin-3.microRNA dysregulation in polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cellsRescue of ATXN3 neuronal toxicity in Caenorhabditiselegans by chemical modification of endoplasmic reticulum stress.Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease.
P2860
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P2860
Nuclear aggregation of polyglutamine-expanded ataxin-3: fragments escape the cytoplasmic quality control.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Nuclear aggregation of polyglu ...... e cytoplasmic quality control.
@ast
Nuclear aggregation of polyglu ...... e cytoplasmic quality control.
@en
type
label
Nuclear aggregation of polyglu ...... e cytoplasmic quality control.
@ast
Nuclear aggregation of polyglu ...... e cytoplasmic quality control.
@en
prefLabel
Nuclear aggregation of polyglu ...... e cytoplasmic quality control.
@ast
Nuclear aggregation of polyglu ...... e cytoplasmic quality control.
@en
P2093
P2860
P356
P1476
Nuclear aggregation of polyglu ...... e cytoplasmic quality control.
@en
P2093
Annette Haacke
Bernd O Evert
Peter Breuer
P2860
P304
P356
10.1074/JBC.M109.036335
P407
P577
2010-01-11T00:00:00Z