Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer.
about
A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of SykProteomic changes resulting from gene copy number variations in cancer cellsEGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells.Novel nonphosphorylated peptides with conserved sequences selectively bind to Grb7 SH2 domain with affinity comparable to its phosphorylated ligand.Progress towards the development of SH2 domain inhibitors.Benefits of biomarker selection and clinico-pathological covariate inclusion in breast cancer prognostic modelsGrb7 gene amplification and protein expression by FISH and IHC in ovarian cancer.Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells.Dissecting GRB7-mediated signals for proliferation and migration in HER2 overexpressing breast tumor cells: GTP-ase rules.Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.HER-2 gene amplification in human breast cancer without concurrent HER-2 over-expression.Chromatin modifications sequentially enhance ErbB2 expression in ErbB2-positive breast cancers.Preparation of crystals for characterizing the Grb7 SH2 domain before and after complex formation with a bicyclic peptide antagonist.Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancerNon-HER2 signaling pathways activated in resistance to anti-HER2 therapy in breast cancer.Validation of analytical breast cancer microarray analysis in medical laboratory.Context-dependent role of Grb7 in HER2+ve and triple-negative breast cancer cell lines.Interaction of the non-phosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity.GRB7 is required for triple-negative breast cancer cell invasion and survival.Ancestry as a potential modifier of gene expression in breast tumors from Colombian women.Design and testing of bicyclic inhibitors of Grb7--are two cycles better than one?Breast cancer in Latinas: a focus on intrinsic subtypes distribution.Methylation-associated silencing of miR-193a-3p promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK/ERK pathways.GRB7 protein over-expression and clinical outcome in breast cancer.
P2860
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P2860
Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer.
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Growth factor receptor-bound p ...... eutic target in breast cancer.
@ast
Growth factor receptor-bound p ...... eutic target in breast cancer.
@en
type
label
Growth factor receptor-bound p ...... eutic target in breast cancer.
@ast
Growth factor receptor-bound p ...... eutic target in breast cancer.
@en
prefLabel
Growth factor receptor-bound p ...... eutic target in breast cancer.
@ast
Growth factor receptor-bound p ...... eutic target in breast cancer.
@en
P2093
P2860
P356
P1433
P1476
Growth factor receptor-bound p ...... eutic target in breast cancer.
@en
P2093
P2860
P304
P356
10.1093/ANNONC/MDP346
P577
2009-08-28T00:00:00Z