Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors. - Test2 - elhamkhani - TriplyDB

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors.

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors.

http://www.wikidata.org/entity/Q33717685

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Pathophysiological power of improper tonic GABA(A) conductances in mature and immature models.Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibition GABA A receptors: subtypes provide diversity of function and pharmacology International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update Role of neurosteroids in the anticonvulsant activity of midazolam Neurosteroids: endogenous role in the human brain and therapeutic potentials Regulation of cortical microcircuits by unitary GABA-mediated volume transmission Neurosteroid regulation of central nervous system development Diverse mechanisms of antiepileptic drugs in the development pipeline Molecular targets for antiepileptic drug development Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function The role of ovarian hormone-derived neurosteroids on the regulation of GABAA receptors in affective disorders Methods for recording and measuring tonic GABAA receptor-mediated inhibition Functional regulation of GABAA receptors in nervous system pathologies Stress, seizures, and hypothalamic-pituitary-adrenal axis targets for the treatment of epilepsy Molecular aspects of age-related cognitive decline: the role of GABA signaling Neurosteroids and their role in sex-specific epilepsies Tonic GABAA Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy.Endozepines Current investigational drugs for major depression Neurosteroids: endogenous regulators of the GABA(A) receptor γ-Hydroxybutyric acid (GHB) is not an agonist of extrasynaptic GABAA receptors Proton modulation of alpha 1 beta 3 delta GABAA receptor channel gating and desensitization Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission In the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cells Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout mice GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol Neurosteroid-sensitive δ-GABAA receptors: A role in epileptogenesis?GABA receptor subunit distribution and FMRP-mGluR5 signaling abnormalities in the cerebellum of subjects with schizophrenia, mood disorders, and autism.N-methyl-D-aspartic acid receptor activation downregulates expression of δ subunit-containing GABAA receptors in cultured hippocampal neurons.A stress steroid triggers anxiety via increased expression of α4βδ GABAA receptors in methamphetamine dependence.Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animals The influence of stress at puberty on mood and learning: role of the α4βδ GABAA receptor Effects of a low dose of ethanol in an animal model of premenstrual anxiety.Endogenous neurosteroid synthesis modulates seizure frequency.Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice.Anxiety sensitivity, the menstrual cycle, and panic disorder: a putative neuroendocrine and psychological interaction.

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P2860

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors.

http://www.wikidata.org/entity/Q33717685

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2003 nî lūn-bûn

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2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2003 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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Neuroactive steroids reduce ne ...... it-containing GABAA receptors.

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Proceedings of the National Academy of Sciences of the United States of America

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Neuroactive steroids reduce ne ...... it-containing GABAA receptors.

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Brandon M Stell

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C Y Tang

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Istvan Mody

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Mark Farrant

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Stephen G Brickley

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P2860

Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors

Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors

Neuroactive steroids

Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells

Development of action potential-dependent and independent spontaneous GABAA receptor-mediated currents in granule cells of postnatal rat cerebellum

Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cells

Cerebellar GABAA receptor selective for a behavioural alcohol antagonist

Paradoxical reduction of synaptic inhibition by vigabatrin

Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.

In vivo monitoring of amino acids by direct sampling of brain extracellular fluid at ultralow flow rates and capillary electrophoresis.

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