Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors.
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Pathophysiological power of improper tonic GABA(A) conductances in mature and immature models.Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibitionGABA A receptors: subtypes provide diversity of function and pharmacologyInternational Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. UpdateRole of neurosteroids in the anticonvulsant activity of midazolamNeurosteroids: endogenous role in the human brain and therapeutic potentialsRegulation of cortical microcircuits by unitary GABA-mediated volume transmissionNeurosteroid regulation of central nervous system developmentDiverse mechanisms of antiepileptic drugs in the development pipelineMolecular targets for antiepileptic drug developmentPotentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to FunctionThe role of ovarian hormone-derived neurosteroids on the regulation of GABAA receptors in affective disordersMethods for recording and measuring tonic GABAA receptor-mediated inhibitionFunctional regulation of GABAA receptors in nervous system pathologiesStress, seizures, and hypothalamic-pituitary-adrenal axis targets for the treatment of epilepsyMolecular aspects of age-related cognitive decline: the role of GABA signalingNeurosteroids and their role in sex-specific epilepsiesTonic GABAA Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy.EndozepinesCurrent investigational drugs for major depressionNeurosteroids: endogenous regulators of the GABA(A) receptorγ-Hydroxybutyric acid (GHB) is not an agonist of extrasynaptic GABAA receptorsProton modulation of alpha 1 beta 3 delta GABAA receptor channel gating and desensitizationRat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinitiesPhospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmissionIn the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cellsContributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 geneIncreased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout miceGABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadolNeurosteroid-sensitive δ-GABAA receptors: A role in epileptogenesis?GABA receptor subunit distribution and FMRP-mGluR5 signaling abnormalities in the cerebellum of subjects with schizophrenia, mood disorders, and autism.N-methyl-D-aspartic acid receptor activation downregulates expression of δ subunit-containing GABAA receptors in cultured hippocampal neurons.A stress steroid triggers anxiety via increased expression of α4βδ GABAA receptors in methamphetamine dependence.Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animalsThe influence of stress at puberty on mood and learning: role of the α4βδ GABAA receptorEffects of a low dose of ethanol in an animal model of premenstrual anxiety.Endogenous neurosteroid synthesis modulates seizure frequency.Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice.Anxiety sensitivity, the menstrual cycle, and panic disorder: a putative neuroendocrine and psychological interaction.
P2860
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P2860
Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors.
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Neuroactive steroids reduce ne ...... it-containing GABAA receptors.
@ast
Neuroactive steroids reduce ne ...... it-containing GABAA receptors.
@en
type
label
Neuroactive steroids reduce ne ...... it-containing GABAA receptors.
@ast
Neuroactive steroids reduce ne ...... it-containing GABAA receptors.
@en
prefLabel
Neuroactive steroids reduce ne ...... it-containing GABAA receptors.
@ast
Neuroactive steroids reduce ne ...... it-containing GABAA receptors.
@en
P2093
P2860
P356
P1476
Neuroactive steroids reduce ne ...... it-containing GABAA receptors.
@en
P2093
Brandon M Stell
Istvan Mody
Mark Farrant
Stephen G Brickley
P2860
P304
14439-14444
P356
10.1073/PNAS.2435457100
P407
P577
2003-11-17T00:00:00Z