Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.

Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.

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http://www.wikidata.org/entity/Q33732534

Q33732534

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Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells.Inhibiting CCN1 blocks AML cell growth by disrupting the MEK/ERK pathway.MDM2, MDMX and p53 in oncogenesis and cancer therapy Targeting p53 by small molecules in hematological malignancies.Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma Clinically relevant genes and regulatory pathways associated with NRASQ61 mutations in melanoma through an integrative genomics approach.Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097 Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk.Functional divergence and convergence between the transcript network and gene network in lung adenocarcinoma.MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex Pharmacologic activation of p53 by small-molecule MDM2 antagonists MEK inhibitors selectively suppress alloreactivity and graft-versus-host disease in a memory stage-dependent manner.HDAC Inhibition Induces MicroRNA-182, which Targets RAD51 and Impairs HR Repair to Sensitize Cells to Sapacitabine in Acute Myelogenous Leukemia BH3 profiling discriminates response to cytarabine-based treatment of acute myelogenous leukemia RALB provides critical survival signals downstream of Ras in acute myeloid leukemia The p53 tumor suppressor protein regulates hematopoietic stem cell fate.Applications of post-translational modifications of FoxO family proteins in biological functions.The Bcl-2/Bax and Ras/Raf/MEK/ERK signaling pathways: implications in pediatric leukemia pathogenesis and new prospects for therapeutic approaches.Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic Targeting MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways.Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies.The increase in BIK expression following ERK1/2 pathway inhibition is a consequence of G₁ cell-cycle arrest and not a direct effect on BIK protein stability.Treatment of Relapsed/Refractory Acute Myeloid Leukemia.The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance.A phase I trial of the human double minute 2 inhibitor (MK-8242) in patients with refractory/recurrent acute myelogenous leukemia (AML).Targeting apoptosis in acute myeloid leukaemia.Synergistic activity and heterogeneous acquired resistance of combined MDM2 and MEK inhibition in KRAS mutant cancers.Targeting Ras signaling in AML: RALB is a small GTPase with big potential.Targeting BTK through microRNA in chronic lymphocytic leukemia.

P2860

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P2860

Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.

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http://www.wikidata.org/entity/Q33732534

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