Gabapentin acts within the locus coeruleus to alleviate neuropathic pain
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The perception and endogenous modulation of painActivation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats.Gabapentin enacarbil - clinical efficacy in restless legs syndromeSpinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal functionSocietal and individual burden of illness among fibromyalgia patients in France: association between disease severity and OMERACT core domains.A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury.Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brainDexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley ratEngagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain.Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes.Spinal cord stimulation modulates supraspinal centers of the descending antinociceptive system in rats with unilateral spinal nerve injury.Gabapentin inhibits catecholamine release from adrenal chromaffin cellsGabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in ratsDepletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injuryPregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiologyDown-regulation of astroglial glutamate transporter-1 in the locus coeruleus impairs pain-evoked endogenous analgesia in ratsNitrous oxide persistently alleviates pain hypersensitivity in neuropathic rats: A dose-dependent effectOndansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of γ-aminobutyric acid in α2-adrenoceptor and 5-HT3 serotonin receptor analgesia.Opioid analgesics increase incidence of somnolence and dizziness as adverse effects of pregabalin: a retrospective study.Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.The use of gabapentin to decrease morphine consumption after surgical debridement for burns.Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms.Pharmacological treatment of neuropathic cancer pain: a comprehensive review of the current literature.Spinal mechanisms of pain and analgesia.Implications and mechanism of action of gabapentin in neuropathic pain.The noradrenergic locus coeruleus as a chronic pain generator.A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA.Glial cell line-derived neurotrophic factor-mediated enhancement of noradrenergic descending inhibition in the locus coeruleus exerts prolonged analgesia in neuropathic pain.Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α(2)δ-1 Subunit in Rats with Central Post-Stroke Pain HypersensitivityDonepezil provides positive effects to patients treated with gabapentin for neuropathic pain: an exploratory study.Vendor-derived differences in injury-induced pain phenotype and pharmacology of Sprague-Dawley rats: Does it matter?Brainstem facilitations and descending serotonergic controls contribute to visceral nociception but not pregabalin analgesia in rats.Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleusActivation of NK₁ receptors in the locus coeruleus induces analgesia through noradrenergic-mediated descending inhibition in a rat model of neuropathic painFunctional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats.Neuronal hyperactivity at the spinal cord and periaqueductal grey during painful diabetic neuropathy: effects of gabapentin.The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain.Bimodal Modulation of Ipsilateral Spinal-Coeruleo-Spinal Pathway in CRPS: A Novel Model for Explaining Different Clinical Features of the Syndrome.The plasticity of descending controls in pain: translational probing.The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain.
P2860
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P2860
Gabapentin acts within the locus coeruleus to alleviate neuropathic pain
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Gabapentin acts within the locus coeruleus to alleviate neuropathic pain
@ast
Gabapentin acts within the locus coeruleus to alleviate neuropathic pain
@en
type
label
Gabapentin acts within the locus coeruleus to alleviate neuropathic pain
@ast
Gabapentin acts within the locus coeruleus to alleviate neuropathic pain
@en
prefLabel
Gabapentin acts within the locus coeruleus to alleviate neuropathic pain
@ast
Gabapentin acts within the locus coeruleus to alleviate neuropathic pain
@en
P2093
P2860
P1433
P1476
Gabapentin acts within the locus coeruleus to alleviate neuropathic pain
@en
P2093
Hideaki Obata
Ken-Ichiro Hayashida
Kunie Nakajima
P2860
P304
P356
10.1097/ALN.0B013E31818DAC9C
P407
P577
2008-12-01T00:00:00Z