ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.
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Alzheimer mechanisms and therapeutic strategiesArf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine developmentGene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brainApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitroApolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's diseaseApolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer diseaseThe dendritic hypothesis for Alzheimer's disease pathophysiology.Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapyReduced hippocampal volume in healthy young ApoE4 carriers: an MRI studyDendritic spine pathology in neuropsychiatric disordersTracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkersGene sequences regulating the production of apoE and cerebral palsy of variable severity.Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learningApolipoprotein E polymorphisms and severity of cerebral palsy: a cross-sectional study in 255 children in Norway.Impact of apolipoprotein E ε4 and HIV on cognition and brain atrophy: antagonistic pleiotropy and premature brain aging.Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctorsApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice.Opposing effects of Apoe/Apoa1 double deletion on amyloid-β pathology and cognitive performance in APP mice.Low-doses of cisplatin injure hippocampal synapses: a mechanism for 'chemo' brain?APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease.Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2.Spatial memory deficits in a mouse model of late-onset Alzheimer's disease are caused by zinc supplementation and correlate with amyloid-beta levelsApoE receptor 2 regulates synapse and dendritic spine formationAltered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice.Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.Apolipoprotein E in synaptic plasticity and Alzheimer's disease: potential cellular and molecular mechanisms.Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development.CNF1 increases brain energy level, counteracts neuroinflammatory markers and rescues cognitive deficits in a murine model of Alzheimer's disease.Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interactionTransgenic animal models of neurodegeneration based on human genetic studies.Impaired regulation of synaptic actin cytoskeleton in Alzheimer's disease.Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice.APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice.Introducing Human APOE into Aβ Transgenic Mouse Models.A combined effect of two Alzheimer's risk genes on medial temporal activity during executive attention in young adults.Presence of ApoE ε4 allele associated with thinner frontal cortex in middle age.Rapid estradiol modulation of neuronal connectivity and its implications for disease.Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity.Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortexAPOE genotype affects the pre-synaptic compartment of glutamatergic nerve terminals
P2860
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P2860
ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.
@ast
ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.
@en
type
label
ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.
@ast
ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.
@en
prefLabel
ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.
@ast
ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.
@en
P2093
P2860
P1476
ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo
@en
P2093
Edwin J Weeber
G William Rebeck
Hyang-Sook Hoe
Joseph A Tesoriero
Justin H Trotter
Lenard W Babus
Madeline T Nguyen
Sonya B Dumanis
P2860
P304
15317-15322
P356
10.1523/JNEUROSCI.4026-09.2009
P407
P577
2009-12-01T00:00:00Z