Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter
about
The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cellsThe Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in DiseaseIdentification of age-specific Nrf2 binding to a novel antioxidant response element locus in the Gclc promoter: a compensatory means for the loss of glutathione synthetic capacity in the aging rat liver?Reactivation of L1 retrotransposon by benzo(a)pyrene involves complex genetic and epigenetic regulationDiscretization provides a conceptually simple tool to build expression networksAberrant epigenetic silencing is triggered by a transient reduction in gene expressionIn vivo expression of MHC class I genes depends on the presence of a downstream barrier elementDistinct epigenetic domains separated by a CTCF bound insulator between the tandem genes, BLU and RASSF1ARelationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks.Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expressionMyxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells.ABCB4 is frequently epigenetically silenced in human cancers and inhibits tumor growthFrequent epigenetic inactivation of cystatin M in breast carcinoma.Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island.Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing.Epigenetic silencing of erythropoietin in human cancersEffects of cytosine methylation on transcription factor binding sitesOCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genesTranscriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized.DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosisAbnormal histone methylation is responsible for increased vascular endothelial growth factor 165a secretion from airway smooth muscle cells in asthma.Abnormal DNA methylation in oocytes could be associated with a decrease in reproductive potential in old mice.Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-islandAutoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasisEpigenetic tête-à-tête: the bilateral relationship between chromatin modifications and DNA methylation.Molecular biomarkers for cancer detection in blood and bodily fluids.Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter.Long-term low level glucocorticoid exposure induces persistent repression in chromatin.DNA methylation patterns in lung carcinomas.Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary.Tumour necrosis factor gene polymorphism and disease prevalence.Epigenetic control of cytokine gene expression: regulation of the TNF/LT locus and T helper cell differentiation.Epigenetic therapy in non-small-cell lung cancer: targeting DNA methyltransferases and histone deacetylases.Epigenetic modifications in prostate cancer.Sp1 and the 'hallmarks of cancer'.Delineating the effect of demethylating agent 5-aza-2'-deoxycytidine on human Caco-2 colonic carcinoma cells.Aberrantly silenced promoters retain a persistent memory of the silenced state after long-term reactivation.Gene promoter methylation in prostate tumor-associated stromal cells.Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer.Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease.
P2860
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P2860
Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter
description
2005 nî lūn-bûn
@nan
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Chromatin inactivation precede ...... encing of the RASSF1A promoter
@ast
Chromatin inactivation precede ...... encing of the RASSF1A promoter
@en
type
label
Chromatin inactivation precede ...... encing of the RASSF1A promoter
@ast
Chromatin inactivation precede ...... encing of the RASSF1A promoter
@en
prefLabel
Chromatin inactivation precede ...... encing of the RASSF1A promoter
@ast
Chromatin inactivation precede ...... encing of the RASSF1A promoter
@en
P2093
P2860
P1476
Chromatin inactivation precede ...... encing of the RASSF1A promoter
@en
P2093
Astrid Kehlen
James C Garbe
Maria Strunnikova
Martha R Stampfer
Reinhard Dammann
Undraga Schagdarsurengin
P2860
P304
P356
10.1128/MCB.25.10.3923-3933.2005
P407
P577
2005-05-01T00:00:00Z