Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity - Test2 - elhamkhani - TriplyDB

Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity

Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity

http://www.wikidata.org/entity/Q33771993

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The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C Anti-cancer drugs elicit re-expression of UDP-glucuronosyltransferases in melanoma cells Two Medicago truncatula half-ABC transporters are essential for arbuscule development in arbuscular mycorrhizal symbiosis Absolute quantification of UGT1A1 in various tissues and cell lines using isotope label-free UPLC-MS/MS method determines its turnover number and correlates with its glucuronidation activities.Brain-derived neurotrophic factor involved epigenetic repression of UGT2B7 in colorectal carcinoma: A mechanism to alter morphine glucuronidation in tumor.Redox regulation in cancer: a double-edged sword with therapeutic potential.Regulated phosphorylation of a major UDP-glucuronosyltransferase isozyme by tyrosine kinases dictates endogenous substrate selection for detoxification.Analysis of R- and S-hydroxywarfarin glucuronidation catalyzed by human liver microsomes and recombinant UDP-glucuronosyltransferases Differences in the glucuronidation of resveratrol and pterostilbene: altered enzyme specificity and potential gender differences Targeted inhibition of glucuronidation markedly improves drug efficacy in mice - a model.Protein kinase Cα and Src kinase support human prostate-distributed dihydrotestosterone-metabolizing UDP-glucuronosyltransferase 2B15 activity.First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics.Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers Intestinal UGTs as potential modifiers of pharmacokinetics and biological responses to drugs and xenobiotics.Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancer Genetic polymorphism in metabolism and host defense enzymes: implications for human health risk assessment.Transcriptional regulation of human UDP-glucuronosyltransferase genes.Posttranscriptional regulation of uridine diphosphate glucuronosyltransferases.Regulation of uridine diphosphate-glucuronosyltransferase 1A3 activity by protein phosphorylation.Role for protein kinase C delta in the functional activity of human UGT1A6: implications for drug-drug interactions between PKC inhibitors and UGT1A6.

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P2860

Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity

http://www.wikidata.org/entity/Q33771993

description

2005 nî lūn-bûn

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2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2005 թվականի ապրիլին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity

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Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity

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type

label

Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity

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Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity

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prefLabel

Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity

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Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity

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PNAS.0407872102

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Proceedings of the National Academy of Sciences of the United States of America

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Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity

@en

P2093

Amanda Garza

http://www.w3.org/2001/XMLSchema#string

Ida S Owens

http://www.w3.org/2001/XMLSchema#string

Juan Rivera

http://www.w3.org/2001/XMLSchema#string

Martina Kovarova

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Nikhil K Basu

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Partha S Mitra

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Rajat Banerjee

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Shigeki Kubota

http://www.w3.org/2001/XMLSchema#string

Tapas Saha

http://www.w3.org/2001/XMLSchema#string

P2860

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells

Molecular genetics of steroid 5 alpha-reductase 2 deficiency

Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation

Localization of protein kinases by anchoring proteins: a theme in signal transduction

Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C.

Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient.

Altered coding for a strictly conserved di-glycine in the major bilirubin UDP-glucuronosyltransferase of a Crigler-Najjar type I patient.

Evidence for overlapping active sites for 17 alpha-ethynlestradiol and bilirubin in the human major bilirubin UDPglucuronosyltransferase.

Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.

Functional effects of overexpression of protein kinase C-alpha, -beta, -delta, -epsilon, and -eta in the mast cell line RBL-2H3.

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6285-6290

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10.1073/PNAS.0407872102

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18

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102

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phosphorylation

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