Loss of IkappaB alpha-mediated control over nuclear import and DNA binding enables oncogenic activation of c-Rel
about
Mutational analysis of the v-Rel dimerization interface reveals a critical role for v-Rel homodimers in transformationOptogenetic control of nuclear protein export.The c-Rel transcription factor and B-cell proliferation: a deal with the devilSelective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian CellsInduction of apoptosis by TPA and VP-16 is through translocation of TR3A novel chromosome region maintenance 1-independent nuclear export signal of the large form of hepatitis delta antigen that is required for the viral assembly.Adducin family proteins possess different nuclear export potentialsMultiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel.Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalphaDifferential regulation of the inhibitor of apoptosis ch-IAP1 by v-rel and the proto-oncogene c-rel.A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes.David and Goliath: chemical perturbation of eukaryotes by bacteria.Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family.Nuclear import of IkappaBalpha is accomplished by a ran-independent transport pathway.Postrepression activation of NF-kappaB requires the amino-terminal nuclear export signal specific to IkappaBalpha.Cytoplasmic sequestration of rel proteins by IkappaBalpha requires CRM1-dependent nuclear export.Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viabilityRegulation of c-Rel nuclear localization by binding of Ca2+/calmodulin.The activation of TC10, a Rho small GTPase, contributes to v-Rel-mediated transformation.The N-terminal nuclear export sequence of IkappaBalpha is required for RanGTP-dependent binding to CRM1.Mutant envelope residues confer a transactivation function onto N-terminal sequences of the v-Rel oncoprotein.CRM1-mediated nuclear export is present during porcine embryogenesis, but is not required for early cleavage.Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells.Interleukin-10 (IL-10) mediated suppression of IL-12 production in RAW 264.7 cells also involves c-rel transcription factor.Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP.
P2860
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P2860
Loss of IkappaB alpha-mediated control over nuclear import and DNA binding enables oncogenic activation of c-Rel
description
1998 nî lūn-bûn
@nan
1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Loss of IkappaB alpha-mediated ...... oncogenic activation of c-Rel
@ast
Loss of IkappaB alpha-mediated ...... oncogenic activation of c-Rel
@en
type
label
Loss of IkappaB alpha-mediated ...... oncogenic activation of c-Rel
@ast
Loss of IkappaB alpha-mediated ...... oncogenic activation of c-Rel
@en
prefLabel
Loss of IkappaB alpha-mediated ...... oncogenic activation of c-Rel
@ast
Loss of IkappaB alpha-mediated ...... oncogenic activation of c-Rel
@en
P2860
P356
P1476
Loss of IkappaB alpha-mediated ...... oncogenic activation of c-Rel
@en
P2093
P2860
P304
P356
10.1128/MCB.18.9.5445
P407
P577
1998-09-01T00:00:00Z