cGAS is essential for cellular senescence. - Test2 - elhamkhani - TriplyDB

cGAS is essential for cellular senescence.

cGAS is essential for cellular senescence.

http://www.wikidata.org/entity/Q33790789

about

Markers of T Cell Senescence in Humans.DNA damage-induced immune response: Micronuclei provide key platform.Anti-inflammaging effects of human alpha-1 antitrypsin.Cytoplasmic chromatin triggers inflammation in senescence and cancer.Is inflammatory micronucleation the key to a successful anti-mitotic cancer drug?Cytosolic sensing of immuno-stimulatory DNA, the enemy within.STING-associated vasculopathy develops independently of IRF3 in mice.Emerging roles of extracellular vesicles in cellular senescence and aging.Cancer biology: Genome jail-break triggers lockdown.Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production.Mitochondrial (Dys) Function in Inflammaging: Do MitomiRs Influence the Energetic, Oxidative, and Inflammatory Status of Senescent Cells?Perturbing mitosis for anti-cancer therapy: is cell death the only answer?Nuclear envelope rupture: little holes, big openings.Chromosomal instability drives metastasis through a cytosolic DNA response.STING-dependent translation inhibition restricts RNA virus replication.DNA sensing in senescence.A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.Mechanisms and functions of cellular senescence.Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells.A High Content Screen in Macrophages Identifies Small Molecule Modulators of STING-IRF3 and NFkB Signaling.Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING.Causes and consequences of genomic instability in laminopathies: replication stress and interferon response.The Regulation of cGAS.RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses.CD36 initiates the secretory phenotype during the establishment of cellular senescence "Toll-free" pathways for production of type I interferons FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence Ageing, Cellular Senescence and Neurodegenerative Disease

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P2860

cGAS is essential for cellular senescence.

http://www.wikidata.org/entity/Q33790789

description

2017 nî lūn-bûn

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2017 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2017 թվականի մայիսին հրատարակված գիտական հոդված

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2017年の論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年论文

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name

cGAS is essential for cellular senescence.

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cGAS is essential for cellular senescence.

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type

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cGAS is essential for cellular senescence.

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cGAS is essential for cellular senescence.

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cGAS is essential for cellular senescence.

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cGAS is essential for cellular senescence.

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PNAS.1705499114

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Proceedings of the National Academy of Sciences of the United States of America

P1476

cGAS is essential for cellular senescence.

@en

P2093

Hanze Wang

http://www.w3.org/2001/XMLSchema#string

Hui Yang

http://www.w3.org/2001/XMLSchema#string

Junyao Ren

http://www.w3.org/2001/XMLSchema#string

Qi Chen

http://www.w3.org/2001/XMLSchema#string

Zhijian J Chen

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P2860

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

Cellular senescence in aging and age-related disease: from mechanisms to therapy

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

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10.1073/PNAS.1705499114

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114

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