Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. - Test2 - elhamkhani - TriplyDB

Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.

Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.

http://www.wikidata.org/entity/Q33791610

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Targeting Th17 Cells with Small Molecules and Small Interference RNA Integrating canonical and metabolic signalling programmes in the regulation of T cell responses Defining the functional states of Th17 cells The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγ Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition.Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.Transcription factor co-occupied regions in the murine genome constitute T-helper-cell subtype-specific enhancers.RORγ antagonists and inverse agonists: a patent review.RORγt-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cells Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation.Small-molecule control of cytokine function: new opportunities for treating immune disorders Emergence of Chinese drug discovery research: impact of hit and lead identification.PLZF regulates CCR6 and is critical for the acquisition and maintenance of the Th17 phenotype in human cells.Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells.High-density P300 enhancers control cell state transitions.CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism.Digoxin Inhibits Induction of Experimental Autoimmune Uveitis in Mice, but Causes Severe Retinal Degeneration RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression.ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer.Tiam1/Rac1 complex controls Il17a transcription and autoimmunity.Protein C receptor (PROCR) is a negative regulator of Th17 pathogenicity.Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations.Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging.Unexpected targets and triggers of autoimmunity.Yin-Yang Regulation of RORγt Protein Complex in Th17 Differentiation.Th17 cells in autoimmune diseases.In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists.Brodalumab -an IL-17RA monoclonal antibody for psoriasis and psoriatic arthritis.Harnessing the Therapeutic Potential of Th17 Cells.T-bet as a key regulator of mucosal immunity.A review of emerging IL-17 inhibitors in the treatment of psoriasis focusing on preclinical through phase II studies.Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases.

P2860

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P2860

Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.

http://www.wikidata.org/entity/Q33791610

description

2014 nî lūn-bûn

@nan

2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի ապրիլին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Small-molecule RORγt antagonis ...... twork by divergent mechanisms.

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Small-molecule RORγt antagonis ...... twork by divergent mechanisms.

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type

label

Small-molecule RORγt antagonis ...... twork by divergent mechanisms.

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Small-molecule RORγt antagonis ...... twork by divergent mechanisms.

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prefLabel

Small-molecule RORγt antagonis ...... twork by divergent mechanisms.

@ast

Small-molecule RORγt antagonis ...... twork by divergent mechanisms.

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J.IMMUNI.2014.04.004

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Small-molecule RORγt antagonis ...... twork by divergent mechanisms.

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Alexander Marson

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Chen Zhu

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Darby Schmidt

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Erkan Baloglu

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Jianfei Yang

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Jinsong Wang

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Karsten Kretschmer

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Ling Zhou

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Mark S Sundrud

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Mercedes Lobera

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P2860

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways

Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

IL-17 and Th17 Cells

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

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477-489

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261765909

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24745332

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