From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects.
about
Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests.A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitorsReference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use.Toxicogenomics directory of chemically exposed human hepatocytes.Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration.Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells.Expression classifiers for developmental toxicants.Identification of carcinogens by a selected panel of DNA damage response associated genes.In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities.Can Valproic Acid Regulate Neurogenesis from Nestin+ Cells in the Adult Midbrain?Highlight report: Cardiotoxicity screening.Innovation in medicine: Ignaz the reviled and Egas the regaled.Transcriptome based differentiation of harmless, teratogenetic and cytotoxic concentration ranges of valproic acid.Adverse outcome pathways: opportunities, limitations and open questionsThe body-on-a-chip concept: possibilities and limitationsToxicology: a discipline in need of academic anchoring--the point of view of the German Society of Toxicology.From smoking guns to footprints: mining for critical events of toxicity pathways in transcriptome data.Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay.Highlight report: Interspecies extrapolation by physiologically based pharmacokinetic modeling.Highlight report: xenobiotic-metabolizing enzymes in skin models.Current research on experimental and applied animal sciences.Rotenone exerts developmental neurotoxicity in a human brain spheroid model.Progress in 'body-on-a-chip' research.Highlight report: acetaminophen hepatotoxicity.Highlight report: pluripotent stem cells in translational research.
P2860
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P2860
From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects.
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
From transient transcriptome r ...... and irreversible drug effects.
@ast
From transient transcriptome r ...... and irreversible drug effects.
@en
type
label
From transient transcriptome r ...... and irreversible drug effects.
@ast
From transient transcriptome r ...... and irreversible drug effects.
@en
prefLabel
From transient transcriptome r ...... and irreversible drug effects.
@ast
From transient transcriptome r ...... and irreversible drug effects.
@en
P2093
P2860
P50
P1476
From transient transcriptome r ...... and irreversible drug effects
@en
P2093
Eugen Rempel
Kesavan Meganathan
Margit Henry
Matthias K Weng
Michael R Berthold
Nina V Balmer
Raivo Kolde
Stefanie Klima
Tanja Waldmann
Violeta N Ivanova
P2860
P2888
P304
P356
10.1007/S00204-014-1279-6
P577
2014-06-17T00:00:00Z
P5875
P6179
1049253012