Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent. - Test2 - elhamkhani - TriplyDB

Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent.

Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent.

http://www.wikidata.org/entity/Q33795953

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α-Cleavage of cellular prion protein The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease Transgenic Rabbits Expressing Ovine PrP Are Susceptible to Scrapie Sialylation of prion protein controls the rate of prion amplification, the cross-species barrier, the ratio of PrPSc glycoform and prion infectivity Effects of FlAsH/tetracysteine (TC) Tag on PrP proteolysis and PrPres formation by TC-scanning.Mammalian prions: tolerance to sequence changes-how far?Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs Protease-resistant prions selectively decrease Shadoo protein.PrP overdrive: does inhibition of α-cleavage contribute to PrP(C) toxicity and prion disease?Glycoform-selective prion formation in sporadic and familial forms of prion disease.Uptake and degradation of protease-sensitive and -resistant forms of abnormal human prion protein aggregates by human astrocytes.Quaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics.Nasal associated lymphoid tissue of the Syrian golden hamster expresses high levels of PrPC.Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases.Generation of a persistently infected MDBK cell line with natural bovine spongiform encephalopathy (BSE).Cellular prion protein regulates its own α-cleavage through ADAM8 in skeletal muscle.Integrity of helix 2-helix 3 domain of the PrP protein is not mandatory for prion replication.Role of prion protein aggregation in neurotoxicity.Mutated but Not Deleted Ovine PrP(C) N-Terminal Polybasic Region Strongly Interferes with Prion Propagation in Transgenic Mice Generating Bona Fide Mammalian Prions with Internal Deletions A specific population of abnormal prion protein aggregates is preferentially taken up by cells and disaggregated in a strain-dependent manner.Highly infectious prions generated by a single round of microplate-based protein misfolding cyclic amplification.A new paradigm for enzymatic control of α-cleavage and β-cleavage of the prion protein.Prion disease tempo determined by host-dependent substrate reduction.Divergent prion strain evolution driven by PrPC expression level in transgenic mice.Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration.Strain-specific role of RNAs in prion replication Comparison of abnormal isoform of prion protein in prion-infected cell lines and primary-cultured neurons by PrPSc-specific immunostaining.Efficient inhibition of infectious prions multiplication and release by targeting the exosomal pathway.MEK1 transduces the prion protein N2 fragment antioxidant effects.Prion propagation in cells expressing PrP glycosylation mutants.Cell Biology Approaches to Studying Prion Diseases.Prion protein facilitates retinal iron uptake and is cleaved at the β-site: Implications for retinal iron homeostasis in prion disorders.Glycoform-independent prion conversion by highly efficient, cell-based, protein misfolding cyclic amplification.Release of Full-Length PrP(C) from Cultured Neurons Following Neurotoxic Challenges Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease.Independent amplification of co-infected long incubation period low conversion efficiency prion strains

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P2860

Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent.

http://www.wikidata.org/entity/Q33795953

description

2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Endogenous proteolytic cleavag ...... ly cell- and tissue-dependent.

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Endogenous proteolytic cleavag ...... ly cell- and tissue-dependent.

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type

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Endogenous proteolytic cleavag ...... ly cell- and tissue-dependent.

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Endogenous proteolytic cleavag ...... ly cell- and tissue-dependent.

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Endogenous proteolytic cleavag ...... ly cell- and tissue-dependent.

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Endogenous proteolytic cleavag ...... ly cell- and tissue-dependent.

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Journal of Biological Chemistry

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Endogenous proteolytic cleavag ...... ly cell- and tissue-dependent.

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Hubert Laude

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Julie Bernard

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Jérôme Chapuis

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Michel Dron

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Mohammed Moudjou

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Muhammad Khalid Farooq Salamat

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Sabrina Cronier

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P2860

Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation

The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein

Specific biarsenical labeling of cell surface proteins allows fluorescent- and biotin-tagging of amyloid precursor protein and prion proteins.

Two Creutzfeldt-Jakob disease agents reproduce prion protein-independent identities in cell cultures.

Rapid and discriminatory diagnosis of scrapie and BSE in retro-pharyngeal lymph nodes of sheep.

Use of thermolysin in the diagnosis of prion diseases.

Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions.

Markedly increased susceptibility to natural sheep scrapie of transgenic mice expressing ovine prp.

Scrapie strains maintain biological phenotypes on propagation in a cell line in culture.

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10252-10264

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10.1074/JBC.M109.083857

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14

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285

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Christelle Langevin

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2010-02-12T00:00:00Z

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41428490

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20154089

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Prion protein family

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2856230

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