Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite.
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Genetic Characterization of Plasmodium Putative Pantothenate Kinase Genes Reveals Their Essential Role in Malaria Parasite Transmission to the MosquitoBiological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathwayIdentification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparumStructural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activityPlasmodium yoelii vitamin B5 pantothenate transporter candidate is essential for parasite transmission to the mosquito.A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasitesA novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway.Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivatedA pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activityVitamin and cofactor biosynthesis pathways in Plasmodium and other apicomplexan parasites.A cross-metathesis approach to novel pantothenamide derivatives.The human malaria parasite Plasmodium falciparum is not dependent on host coenzyme A biosynthesis.Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency.Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activityExploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides.Novel pantothenate derivatives for anti-malarial chemotherapy.Antimicrobial activity of pantothenol against staphylococci possessing a prokaryotic type II pantothenate kinase.Chemical and genetic validation of thiamine utilization as an antimalarial drug target.The antimalarial activity of the pantothenamide α-PanAm is via inhibition of pantothenate phosphorylation.Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite.Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues.
P2860
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P2860
Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite.
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite.
@ast
Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite.
@en
type
label
Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite.
@ast
Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite.
@en
prefLabel
Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite.
@ast
Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite.
@en
P2860
P1476
Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite.
@en
P2093
Isabelle Ferru
P2860
P304
P356
10.1128/AAC.49.2.632-637.2005
P407
P577
2005-02-01T00:00:00Z