GSK3beta: role in therapeutic landscape and development of modulators.
about
GSK-3β: A Bifunctional Role in Cell Death PathwaysDiabetes-associated depression: the serotonergic system as a novel multifunctional targetWnt your brain be inflamed? Yes, it Wnt!Translocation of glycogen synthase kinase-3β (GSK-3β), a trigger of permeability transition, is kinase activity-dependent and mediated by interaction with voltage-dependent anion channel 2 (VDAC2).Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease.UBE2T knockdown inhibits gastric cancer progression.Analysis of the effect of rutin on GSK-3β and TNF-α expression in lung cancerSyntheses, neural protective activities, and inhibition of glycogen synthase kinase-3β of substituted quinolines.Glycogen Synthase Kinase 3β Inhibitor (2'Z,3'E)-6-Bromo-indirubin- 3'-Oxime Enhances Drug Resistance to 5-Fluorouracil Chemotherapy in Colon Cancer Cells.A GSK-3β inhibitor protects against radiation necrosis in mouse brain.cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinaseRegional metabolic heterogeneity of the hippocampus is nonuniformly impacted by age and caloric restriction.Discovery of Novel Antiangiogenic Marine Natural Product Scaffolds.Glycogen synthase kinase 3 inhibitor protects against microvascular hyperpermeability following hemorrhagic shock.Structure-guided design of a highly selective glycogen synthase kinase-3β inhibitor: a superior neuroprotective pyrazolone showing antimania effectsAberrant glycogen synthase kinase 3β in the development of pancreatic cancer.Plasticity of subventricular zone neuroprogenitors in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease involves cross talk between inflammatory and Wnt/β-catenin signaling pathways: functional consequences for nUsing Pharmacokinetic Profiles and Digital Quantification of Stained Tissue Microarrays as a Medium-Throughput, Quantitative Method for Measuring the Kinetics of Early Signaling Changes Following Integrin-Linked Kinase Inhibition in an In Vivo ModelWnt/β-Catenin Regulates the Activity of Epiprofin/Sp6, SHH, FGF, and BMP to Coordinate the Stages of OdontogenesisGsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.GSK-3β: a key regulator of breast cancer drug resistance.MicroRNA-101 reverses temozolomide resistance by inhibition of GSK3β in glioblastoma.Efficacy of glycogen synthase kinase-3β targeting against osteosarcoma via activation of β-cateninMolecular targets underlying SUMO-mediated neuroprotection in brain ischemia.Kinase inhibitors for CNS diseases: an analysis of the recent patent literature.Mitochondria as key targets of cardioprotection in cardiac ischemic disease: role of thyroid hormone triiodothyronine.Phosphatidylinositol 3'-kinase, mTOR, and glycogen synthase kinase-3β mediated regulation of p21 in human urothelial carcinoma cellsGSK3 controls axon growth via CLASP-mediated regulation of growth cone microtubules.Investigation of the bindings of a class of inhibitors with GSK3β kinase using thermodynamic integration MD simulation and kinase assay.BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors: Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells.Bi-phasic regulation of glycogen content in astrocytes via Cav-1/PTEN/PI3K/AKT/GSK-3β pathway by fluoxetine.Orchestrating cellular signaling pathways-the cellular "conductor" protein tyrosine phosphatase interacting protein 51 (PTPIP51).Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment.Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver.GSK3beta Inhibitor Peptide Protects Mice from LPS-induced Endotoxin Shock.GSK-3β inhibition protects mesothelial cells during experimental peritoneal dialysis through upregulation of the heat shock response.GSK3β mediates pancreatic cancer cell invasion in vitro via the CXCR4/MMP-2 Pathway.Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling.Microglia Polarization, Gene-Environment Interactions and Wnt/β-Catenin Signaling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Aged Parkinsonian Brain.Targeting glycogen synthase kinase-3β to prevent hyperoxia-induced lung injury in neonatal rats.
P2860
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P2860
GSK3beta: role in therapeutic landscape and development of modulators.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
GSK3beta: role in therapeutic landscape and development of modulators.
@ast
GSK3beta: role in therapeutic landscape and development of modulators.
@en
type
label
GSK3beta: role in therapeutic landscape and development of modulators.
@ast
GSK3beta: role in therapeutic landscape and development of modulators.
@en
prefLabel
GSK3beta: role in therapeutic landscape and development of modulators.
@ast
GSK3beta: role in therapeutic landscape and development of modulators.
@en
P2093
P2860
P1476
GSK3beta: role in therapeutic landscape and development of modulators.
@en
P2093
P2860
P356
10.1111/J.1476-5381.2010.00661.X
P407
P577
2010-03-19T00:00:00Z