The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure. - Test2 - elhamkhani - TriplyDB

The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure.

The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure.

http://www.wikidata.org/entity/Q33836365

about

The structural basis for intramembrane assembly of an activating immunoreceptor complex The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor Regulation of immune cell function and differentiation by the NKG2D receptor Fine tuning a well-oiled machine: Influence of NK1.1 and NKG2D on NKT cell development and function NKG2D ligands as therapeutic targets Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch.CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12 Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1 Up on the tightrope: natural killer cell activation and inhibition An approach to the immunophenotypic features of circulating CD4⁺NKG2D⁺ T cells in invasive cervical carcinoma.The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site.The SCHOOL of nature: I. Transmembrane signaling.Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.A truncated human NKG2D splice isoform negatively regulates NKG2D-mediated function.DAP12 impacts trafficking and surface stability of killer immunoglobulin-like receptors on natural killer cells Genetics, genomics, and evolutionary biology of NKG2D ligands.NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.MARCH-IX mediates ubiquitination and downregulation of ICAM-1.The SCHOOL of nature: III. From mechanistic understanding to novel therapies NK cells: immune cross-talk and therapeutic implications.Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly.NKG2D Receptor and Its Ligands in Host Defense NKG2D expression by CD8+ T cells contributes to GVHD and GVT effects in a murine model of allogeneic HSCT Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity.Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID)Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the γc cytokines and TGF-β1.Molecular mechanisms underlying KVS-1-MPS-1 complex assembly.Prevalence of the NKG2D Thr72Ala polymorphism in patients with cervical carcinoma.Comparative study of various subpopulations of cytotoxic cells in blood and ascites from patients with ovarian carcinoma.Physiological roles of murine DAP10 adapter protein in tumor immunity and autoimmunity.Substantial increase in the frequency of circulating CD4+NKG2D+ T cells in patients with cervical intraepithelial neoplasia grade 1.NK cells and cancer immunosurveillance.NKG2D ligands in tumor immunity.DAP10- and DAP12-associated receptors in innate immunity.Signal transduction during activation and inhibition of natural killer cells.A conserved αβ transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane.Beyond Stressed Self: Evidence for NKG2D Ligand Expression on Healthy Cells Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes.

P2860

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P2860

The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure.

http://www.wikidata.org/entity/Q33836365

description

2005 nî lūn-bûn

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2005 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2005 թվականի մայիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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The activating NKG2D receptor ...... rs into a hexameric structure.

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The activating NKG2D receptor ...... rs into a hexameric structure.

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The activating NKG2D receptor ...... rs into a hexameric structure.

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The activating NKG2D receptor ...... ers into a hexameric structure

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P2093

David Garrity

http://www.w3.org/2001/XMLSchema#string

Jianwen Feng

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Kai W Wucherpfennig

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P2860

Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB

Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA

An activating immunoreceptor complex formed by NKG2D and DAP10

Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells

ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor

Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA

Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity

Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity

A second lineage of mammalian major histocompatibility complex class I genes

Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A

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102

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Matthew E. Call

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