Identification of an additional gene required for eukaryotic nonsense mRNA turnover. - Test2 - elhamkhani - TriplyDB

Identification of an additional gene required for eukaryotic nonsense mRNA turnover.

Identification of an additional gene required for eukaryotic nonsense mRNA turnover.

http://www.wikidata.org/entity/Q33837730

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Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeast The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast Using the cre-lox recombination system to assess functional impairment caused by amino acid substitutions in yeast proteins Temperature-sensitive mutations in the Saccharomyces cerevisiae MRT4, GRC5, SLA2 and THS1 genes result in defects in mRNA turnover.Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing.Nuclear import of Upf3p is mediated by importin-alpha/-beta and export to the cytoplasm is required for a functional nonsense-mediated mRNA decay pathway in yeast Relationship between yeast polyribosomes and Upf proteins required for nonsense mRNA decay.NMD3 encodes an essential cytoplasmic protein required for stable 60S ribosomal subunits in Saccharomyces cerevisiae.The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1 Nucleotide excision repair/TFIIH helicases RAD3 and SSL2 inhibit short-sequence recombination and Ty1 retrotransposition by similar mechanisms.BUD22 affects Ty1 retrotransposition and ribosome biogenesis in Saccharomyces cerevisiae Posttranscriptional control of gene expression in yeast.Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough.Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein In vivo characterization of the proteasome regulator PA28 Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway Impact of nonsense-mediated mRNA decay on the global expression profile of budding yeast.Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway.Inactivation of NMD increases viability of sup45 nonsense mutants in Saccharomyces cerevisiae.Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegans mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover.Telomere length regulation and telomeric chromatin require the nonsense-mediated mRNA decay pathway.Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA.Yeast Upf proteins required for RNA surveillance affect global expression of the yeast transcriptome.Upf1p, Nmd2p, and Upf3p regulate the decapping and exonucleolytic degradation of both nonsense-containing mRNAs and wild-type mRNAs.Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast Mutations in the MOF2/SUI1 gene affect both translation and nonsense-mediated mRNA decay.Overexpression of truncated Nmd3p inhibits protein synthesis in yeast.Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitution RNA-Seq analysis reveals new gene models and alternative splicing in the fungal pathogen Fusarium graminearum.The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts The Rad27 (Fen-1) nuclease inhibits Ty1 mobility in Saccharomyces cerevisiae.

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P2860

Identification of an additional gene required for eukaryotic nonsense mRNA turnover.

http://www.wikidata.org/entity/Q33837730

description

1995 nî lūn-bûn

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1995 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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1995 թվականի հոտեմբերին հրատարակված գիտական հոդված

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1995年の論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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1995年论文

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name

Identification of an additional gene required for eukaryotic nonsense mRNA turnover.

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Identification of an additional gene required for eukaryotic nonsense mRNA turnover.

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type

label

Identification of an additional gene required for eukaryotic nonsense mRNA turnover.

@ast

Identification of an additional gene required for eukaryotic nonsense mRNA turnover.

@en

prefLabel

Identification of an additional gene required for eukaryotic nonsense mRNA turnover.

@ast

Identification of an additional gene required for eukaryotic nonsense mRNA turnover.

@en

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PNAS.92.22.10354

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Proceedings of the National Academy of Sciences of the United States of America

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Identification of an additional gene required for eukaryotic nonsense mRNA turnover.

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B S Lee

http://www.w3.org/2001/XMLSchema#string

M R Culbertson

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P2860

DNA sequencing with chain-terminating inhibitors

The yeast homolog to mouse Tcp-1 affects microtubule-mediated processes

Transformation of intact yeast cells treated with alkali cations

Nuclear targeting sequences--a consensus?

Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.

The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm.

A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence

The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript

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scholarly article

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