Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
about
Precarious maintenance of simple DNA repeats in eukaryotes.Distinct Mechanisms of Nuclease-Directed DNA-Structure-Induced Genetic Instability in Cancer Genomes.Positioning the 5'-flap junction in the active site controls the rate of flap endonuclease-1-catalyzed DNA cleavage.RNA-DNA hybrids promote the expansion of Friedreich's ataxia (GAA)n repeats via break-induced replication.Missed cleavage opportunities by FEN1 lead to Okazaki fragment maturation via the long-flap pathway.Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1.
P2860
Q39432621-3E10FB64-5EE6-42C8-8029-2BB1470254EDQ49547332-DF4D9DAC-13EC-4BD9-944C-F583D3839703Q49806501-CC0C9E4B-4BE6-4034-863D-A8D745BA4CBAQ49977542-8B6138D3-62E1-4B3A-9C67-163092C88F1AQ50113616-7DCCE699-23FD-49A6-874A-CF75F36891E4Q52326200-853F22A9-F4F1-4A3B-BC0D-FE6E4D9B0818Q54980026-D2248CD8-4458-4ECA-86EE-DE09AAC8B6FDQ55368890-4DE8ADA4-CAAB-46E5-B3F1-5A14C5D40286
P2860
Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
description
2017 nî lūn-bûn
@nan
2017 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2017 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2017年の論文
@ja
2017年論文
@yue
2017年論文
@zh-hant
2017年論文
@zh-hk
2017年論文
@zh-mo
2017年論文
@zh-tw
2017年论文
@wuu
name
Phosphate steering by Flap End ...... to prevent genome instability.
@ast
Phosphate steering by Flap End ...... to prevent genome instability.
@en
type
label
Phosphate steering by Flap End ...... to prevent genome instability.
@ast
Phosphate steering by Flap End ...... to prevent genome instability.
@en
prefLabel
Phosphate steering by Flap End ...... to prevent genome instability.
@ast
Phosphate steering by Flap End ...... to prevent genome instability.
@en
P2093
P2860
P50
P356
P1476
Phosphate steering by Flap End ...... to prevent genome instability.
@en
P2093
Alexander J Neil
Andrew S Arvai
Emma Jardine
Fahad Rashid
Jane A Grasby
L David Finger
Mark J Thompson
Sana I Algasaier
Susan E Tsutakawa
P2860
P2888
P356
10.1038/NCOMMS15855
P407
P577
2017-06-27T00:00:00Z
P6179
1086296420