Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication. - Test2 - elhamkhani - TriplyDB

Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.

Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.

http://www.wikidata.org/entity/Q33878208

about

Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery Viral and Cellular mRNA Translation in Coronavirus-Infected Cells.SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage Eukaryotic initiation factor 4F: a vulnerability of tumor cells.Targeting the eIF4F translation initiation complex: a critical nexus for cancer development Murine norovirus 1 (MNV1) replication induces translational control of the host by regulating eIF4E activity during infection Emerging therapeutics targeting mRNA translation Severe acute respiratory syndrome coronavirus nsp1 facilitates efficient propagation in cells through a specific translational shutoff of host mRNA.Therapeutic interventions to disrupt the protein synthetic machinery in melanoma Reselection of a genomic upstream open reading frame in mouse hepatitis coronavirus 5'-untranslated-region mutants Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover.Tinkering with translation: protein synthesis in virus-infected cells.Non-canonical Translation in Plant RNA Viruses.Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A.4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice.Comparative Proteome Analysis of Porcine Jejunum Tissues in Response to a Virulent Strain of Porcine Epidemic Diarrhea Virus and Its Attenuated Strain.Targeting Hsp27/eIF4E interaction with phenazine compound: a promising alternative for castration-resistant prostate cancer treatment.The p53 target gene TRIM22 directly or indirectly interacts with the translation initiation factor eIF4E and inhibits the binding of eIF4E to eIF4G.Beyond molecular tumor heterogeneity: protein synthesis takes control.Pancreatic tumours escape from translational control through 4E-BP1 loss.Cellular hnRNP A1 Interacts with Nucleocapsid Protein of Porcine Epidemic Diarrhea Virus and Impairs Viral Replication.

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P2860

Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.

http://www.wikidata.org/entity/Q33878208

description

2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.

@ast

Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.

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type

label

Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.

@ast

Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.

@en

prefLabel

Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.

@ast

Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.

@en

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Journal of Virology

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Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication

@en

P2093

David R Hall

http://www.w3.org/2001/XMLSchema#string

Haian Fu

http://www.w3.org/2001/XMLSchema#string

Jaeki Min

http://www.w3.org/2001/XMLSchema#string

Jerry Pelletier

http://www.w3.org/2001/XMLSchema#string

Marc Desforges

http://www.w3.org/2001/XMLSchema#string

Pierre J Talbot

http://www.w3.org/2001/XMLSchema#string

Regina Cencic

http://www.w3.org/2001/XMLSchema#string

Sandor Vajda

http://www.w3.org/2001/XMLSchema#string

Yuhong Du

http://www.w3.org/2001/XMLSchema#string

P2860

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol

Fragment-based identification of druggable 'hot spots' of proteins using Fourier domain correlation techniques.

Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.

Titration of human coronaviruses, HcoV-229E and HCoV-OC43, by an indirect immunoperoxidase assay.

Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29.

Murine coronavirus replication-induced p38 mitogen-activated protein kinase activation promotes interleukin-6 production and virus replication in cultured cells.

Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F

P304

6381-6389

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scholarly article

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10.1128/JVI.00078-11

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P433

13

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P478

85

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Raymond Dingledine

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2011-04-20T00:00:00Z

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P5875

51065452

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21507972

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3126520

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