Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.
about
Clinical significance of T cell metabolic reprogramming in cancerFundamentals of cancer metabolismLactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic RelevanceMYC, Metabolism, and CancerReview of aerobic glycolysis and its key enzymes - new targets for lung cancer therapyRedox control of glutamine utilization in cancerStructures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound formsMetabolic plasticity underpins innate and acquired resistance to LDHA inhibitionTumour biomarkers: homeostasis as a novel prognostic indicatorCaveolin-1 in the regulation of cell metabolism: a cancer perspectiveAdipose tissue dysfunction and its effects on tumor metabolismExpression of Cell-Surface Marker ABCB5 Causes Characteristic Modifications of Glucose, Amino Acid and Phospholipid Metabolism in the G3361 Melanoma-Initiating Cell LineGlycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation.Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation.Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression.Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway.Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasisEndothelial cell metabolism: parallels and divergences with cancer cell metabolismDifferent effects of LDH-A inhibition by oxamate in non-small cell lung cancer cellsOVCAR-3 spheroid-derived cells display distinct metabolic profilesNutrition and metabolic correlates of obesity and inflammation: clinical considerations.Molecular Pathways: Targeting Cellular Energy Metabolism in Cancer via Inhibition of SLC2A1 and LDHADifferentially expressed and activated proteins associated with non small cell lung cancer tissuesSynthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents.Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function.Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.Melanoma brain metastasis is independent of lactate dehydrogenase A expressionIonizing radiation induces myofibroblast differentiation via lactate dehydrogenaseLactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and deathPrognostic relevance of lactate dehydrogenase in advanced pancreatic ductal adenocarcinoma patients.Silver nanoparticles affect glucose metabolism in hepatoma cells through production of reactive oxygen speciesTwist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways.Heme oxygenase-1 in macrophages controls prostate cancer progressionActive glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122.Novel Gefitinib Formulation with Improved Oral Bioavailability in Treatment of A431 Skin Carcinoma.Applications of NMR spectroscopy to systems biochemistry.Metabolic Reprogramming and Dependencies Associated with Epithelial Cancer Stem Cells Independent of the Epithelial-Mesenchymal Transition Program.Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung TumorigenesisA new prognostic score based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer
P2860
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P2860
Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.
description
2014 nî lūn-bûn
@nan
2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Targeting lactate dehydrogenas ...... mpacts tumor-initiating cells.
@ast
Targeting lactate dehydrogenas ...... mpacts tumor-initiating cells.
@en
type
label
Targeting lactate dehydrogenas ...... mpacts tumor-initiating cells.
@ast
Targeting lactate dehydrogenas ...... mpacts tumor-initiating cells.
@en
prefLabel
Targeting lactate dehydrogenas ...... mpacts tumor-initiating cells.
@ast
Targeting lactate dehydrogenas ...... mpacts tumor-initiating cells.
@en
P2093
P2860
P50
P1433
P1476
Targeting lactate dehydrogenas ...... impacts tumor-initiating cells
@en
P2093
Aaron Grant
Andrew N Lane
Jian-Guo Ren
Julia Billiard
Jun-Ichi Hanai
Kerri Burgess
Michael Bousamra
Pankaj Seth
Parul Bhargava
P2860
P304
P356
10.1016/J.CMET.2014.03.003
P577
2014-04-10T00:00:00Z