Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity.
about
Ixabepilone administered weekly or every three weeks in HER2-negative metastatic breast cancer patients; a randomized non-comparative phase II trialA phase II trial of the epothilone B analog ixabepilone (BMS-247550) in patients with metastatic melanoma.Total synthesis and evaluation of C26-hydroxyepothilone D derivatives for photoaffinity labeling of beta-tubulin.Enzymatic synthesis of epothilone A glycosidesLow dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia.Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo.Subcellular distribution of epothilones in human tumor cells.Chemotherapy resistance in metastatic breast cancer: the evolving role of ixabepiloneDynamics of tumor hypoxia in response to patupilone and ionizing radiationIxabepilone-induced mitochondria and sensory axon loss in breast cancer patientsFrom nature to the laboratory and into the clinicMultimodal assessment of painful peripheral neuropathy induced by chronic oxaliplatin-based chemotherapy in miceIntratumoral drug delivery with nanoparticulate carriers.Drugs that target dynamic microtubules: a new molecular perspectiveThe microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells.C6-C8 bridged epothilones: consequences of installing a conformational lock at the edge of the macrocycle.Design and synthesis of C6-C8 bridged epothilone A.Epothilones in epithelial ovarian, fallopian tube, or primary peritoneal cancer: a systematic review.Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modelingThe synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice.Major clinical research advances in gynecologic cancer in 2012.Treatment of neuroblastoma and rhabdomyosarcoma using RGD-modified liposomal formulations of patupilone (EPO906).Can medical herbs stimulate regeneration or neuroprotection and treat neuropathic pain in chemotherapy-induced peripheral neuropathy?Microtubule dynamics as a target in oncology.A phase 1 study of KOS-862 (Epothilone D) co-administered with carboplatin (Paraplatin®) in patients with advanced solid tumorsPhase II trial of patupilone in patients with brain metastases from breast cancer.Microtubule-targeting agents in oncology and therapeutic potential in hepatocellular carcinoma.Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma.The Application of REDOR NMR to Understand the Conformation of Epothilone B.Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies.Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin.Multicenter phase 2 study of patupilone for recurrent or progressive brain metastases from non-small cell lung cancer.Highly Efficient CYP167A1 (EpoK) dependent Epothilone B Formation and Production of 7-Ketone Epothilone D as a New Epothilone Derivative.Microtubule stabilization opposes the (TNF-alpha)-induced loss in the barrier integrity of corneal endothelium.Epothilone B-based 3-in-1 polymeric micelle for anticancer drug therapy.Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones).Patient-Derived Stem Cell Models in HSP: Disease Modelling and Drug Discovery
P2860
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P2860
Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity.
description
2000 nî lūn-bûn
@nan
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Epothilones and related struct ...... nt in vivo antitumor activity.
@ast
Epothilones and related struct ...... nt in vivo antitumor activity.
@en
type
label
Epothilones and related struct ...... nt in vivo antitumor activity.
@ast
Epothilones and related struct ...... nt in vivo antitumor activity.
@en
prefLabel
Epothilones and related struct ...... nt in vivo antitumor activity.
@ast
Epothilones and related struct ...... nt in vivo antitumor activity.
@en
P2093
P1476
Epothilones and related struct ...... nt in vivo antitumor activity.
@en
P2093
K H Altmann
M Wartmann
T O'Reilly
P304
P356
10.1016/S0304-419X(00)00009-3
P407
P577
2000-05-01T00:00:00Z