about
A missense mutation in DHDDS, encoding dehydrodolichyl diphosphate synthase, is associated with autosomal-recessive retinitis pigmentosa in Ashkenazi JewsHuman isoprenoid synthase enzymes as therapeutic targetsProtein prenylation and synaptic plasticity: implications for Alzheimer's diseaseA Pan-GTPase Inhibitor as a Molecular ProbeCross-talk of membrane lipids and Alzheimer-related proteins.Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease.Transcriptome and proteome exploration to provide a resource for the study of Agrocybe aegeritaInhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity.Simvastatin induced neurite outgrowth unveils role of cell surface cholesterol and acetyl CoA carboxylase in SH-SY5Y cells.Linking lipids to Alzheimer's disease: cholesterol and beyond.Life with too much polyprenol: polyprenol reductase deficiency.Amyloid precursor protein controls cholesterol turnover needed for neuronal activity.Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease.High-throughput endogenous measurement of S-nitrosylation in Alzheimer's disease using oxidized cysteine-selective cPILOT.Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease.Impaired geranylgeranyltransferase-I regulation reduces membrane-associated Rho protein levels in aged mouse brain.Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis.The analytical determination of isoprenoid intermediates from the mevalonate pathway.Mitochondrial dysfunction--a pharmacological target in Alzheimer's disease.Alzheimer's disease, cholesterol, and statins: the junctions of important metabolic pathways.Activation of sphingosine-1-phosphate signalling as a potential underlying mechanism of the pleiotropic effects of statin therapy.Statins and neuroprotection: basic pharmacology needed.The Role of Geranylgeranyltransferase I-Mediated Protein Prenylation in the Brain.Aβ-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Aβ Secretion in Neural Cells.Understanding the cholesterol metabolism-perturbing effects of docosahexaenoic acid by gas chromatography-mass spectrometry targeted metabonomic profiling.In vitro Metabolomic Approaches to Investigating the Potential Biological Effects of Phenolic Compounds: An Update.The beneficial effects of HMG-CoA reductase inhibitors in the processes of neurodegeneration.A rapid and sensitive assay for determining human brain levels of farnesyl-(FPP) and geranylgeranylpyrophosphate (GGPP) and transferase activities using UHPLC-MS/MS.Simvastatin Inhibits Cell Proliferation and Migration in Human Anaplastic Thyroid Cancer.Aβ inhibits SREBP-2 activation through Akt inhibition.Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice.Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells.Prenylation of Rho G-proteins: a novel mechanism regulating gene expression and protein stability in human trabecular meshwork cells.The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms.Resveratrol Intervenes Cholesterol- and Isoprenoid-Mediated Amyloidogenic Processing of AβPP in Familial Alzheimer's Disease.Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Isoprenoids, small GTPases and Alzheimer's disease.
@ast
Isoprenoids, small GTPases and Alzheimer's disease.
@en
type
label
Isoprenoids, small GTPases and Alzheimer's disease.
@ast
Isoprenoids, small GTPases and Alzheimer's disease.
@en
prefLabel
Isoprenoids, small GTPases and Alzheimer's disease.
@ast
Isoprenoids, small GTPases and Alzheimer's disease.
@en
P2093
P2860
P1476
Isoprenoids, small GTPases and Alzheimer's disease.
@en
P2093
Gero P Hooff
Gunter P Eckert
W Gibson Wood
Walter E Müller
P2860
P304
P356
10.1016/J.BBALIP.2010.03.014
P407
P577
2010-04-08T00:00:00Z