A single amino acid in nonstructural protein NS4B confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis.
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A lethal murine infection model for dengue virus 3 in AG129 mice deficient in type I and II interferon receptors leads to systemic diseaseMouse models of dengue virus infection for vaccine testingDengue Virus Reporter Replicon is a Valuable Tool for Antiviral Drug Discovery and Analysis of Virus Replication MechanismsFlaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral interventionThe yellow fever 17D virus as a platform for new live attenuated vaccinesMouse models to study dengue virus immunology and pathogenesisUnderstanding the dengue viruses and progress towards their controlSynergistic interactions between the NS3(hel) and E proteins contribute to the virulence of dengue virus type 1Rational design of a live attenuated dengue vaccine: 2'-o-methyltransferase mutants are highly attenuated and immunogenic in mice and macaquesUnderstanding Zika Virus Stability and Developing a Chimeric Vaccine through Functional AnalysisFirst experimental in vivo model of enhanced dengue disease severity through maternally acquired heterotypic dengue antibodiesA Dengue Virus Type 4 Model of Disseminated Lethal Infection in AG129 MiceMaternal Antibody-Mediated Disease Enhancement in Type I Interferon-Deficient Mice Leads to Lethal Disease Associated with Liver DamageType I interferon signals in macrophages and dendritic cells control dengue virus infection: implications for a new mouse model to test dengue vaccinesNsp9 and Nsp10 contribute to the fatal virulence of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China.Novel approaches to flavivirus drug discovery.Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro.Genetic Dissection of the Host Tropism of Human-Tropic Pathogens.Selective susceptibility of human skin antigen presenting cells to productive dengue virus infectionThe flavivirus protease as a target for drug discovery.Hypertonic saline reduces vascular leakage in a mouse model of severe dengue.Mutation of Putative N-Glycosylation Sites on Dengue Virus NS4B Decreases RNA ReplicationA Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral ReplicationThe Complete Genome Phylogeny of Geographically Distinct Dengue Virus Serotype 2 Isolates (1944-2013) Supports Further Groupings within the Cosmopolitan Genotype.Evidence for a genetic and physical interaction between nonstructural proteins NS1 and NS4B that modulates replication of West Nile virusSelection of classical swine fever virus with enhanced pathogenicity reveals synergistic virulence determinants in E2 and NS4BFunctional analysis of antibodies against dengue virus type 4 reveals strain-dependent epitope exposure that impacts neutralization and protection.Population structure of the dengue viruses, Aragua, Venezuela, 2006-2007. Insights into dengue evolution under hyperendemic transmission.The role of endothelial activation in dengue hemorrhagic fever and hantavirus pulmonary syndrome.Animal models of dengue virus infectionAn Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection.A West Nile virus NS4B-P38G mutant strain induces cell intrinsic innate cytokine responses in human monocytic and macrophage cells.Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection.Isolation and characterization of dengue virus serotype 2 from the large dengue outbreak in Guangdong, China in 2014.Molecular evolution and epidemiology of four serotypes of dengue virus in Thailand from 1973 to 2007.Dengue vaccine-induced CD8+ T cell immunity confers protection in the context of enhancing, interfering maternal antibodies.Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein.
P2860
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P2860
A single amino acid in nonstructural protein NS4B confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A single amino acid in nonstru ...... cement of viral RNA synthesis.
@ast
A single amino acid in nonstru ...... cement of viral RNA synthesis.
@en
type
label
A single amino acid in nonstru ...... cement of viral RNA synthesis.
@ast
A single amino acid in nonstru ...... cement of viral RNA synthesis.
@en
prefLabel
A single amino acid in nonstru ...... cement of viral RNA synthesis.
@ast
A single amino acid in nonstru ...... cement of viral RNA synthesis.
@en
P2093
P2860
P50
P356
P1433
P1476
A single amino acid in nonstru ...... cement of viral RNA synthesis.
@en
P2093
Dixon Grant
Grace K Tan
Jowin K W Ng
Mark J Schreiber
Sylvie Alonso
Wouter Schul
Zhiming Yuan
P2860
P304
P356
10.1128/JVI.00665-11
P407
P577
2011-06-01T00:00:00Z