Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss. - Test2 - elhamkhani - TriplyDB

Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss.

Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss.

http://www.wikidata.org/entity/Q33922936

about

Mutation of the INI1 gene in composite rhabdoid tumor of the endometrium ATP-dependent chromatin remodeling complexes as novel targets for cancer therapy SWI/SNF chromatin remodeling complexes and cancer Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression Integrated genetic and pharmacologic interrogation of rare cancers Therapeutically targeting cyclin D1 in primary tumors arising from loss of Ini1.Familial occurrence of schwannomas and malignant rhabdoid tumour associated with a duplication in SMARCB1 Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen.Rhabdoid tumor: gene expression clues to pathogenesis and potential therapeutic targets.Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformation.Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth.Consistent SMARCB1 homozygous deletions in epithelioid sarcoma and in a subset of myoepithelial carcinomas can be reliably detected by FISH in archival material.The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells.Characterization of DNA binding property of the HIV-1 host factor and tumor suppressor protein Integrase Interactor 1 (INI1/hSNF5).Genome-wide approach to identify second gene targets for malignant rhabdoid tumors using high-density oligonucleotide microarrays.HIV-1 replication in cell lines harboring INI1/hSNF5 mutations.p16INK4A and p14ARF tumor suppressor pathways are deregulated in malignant rhabdoid tumors.In vitro activities of novel 4-HPR derivatives on a panel of rhabdoid and other tumor cell lines.Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expression.Atypical teratoid rhabdoid tumor: current therapy and future directions.The requirement for cyclin D function in tumor maintenance.Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells.Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies.Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters An Essential Role of INI1/hSNF5 Chromatin Remodeling Protein in HIV-1 Posttranscriptional Events and Gag/Gag-Pol Stability.The role of INI1/hSNF5 in gene regulation and cancer.The role of SMARCB1/INI1 in development of rhabdoid tumor.Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome.Cell cycle proteins as promising targets in cancer therapy Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins Atypical teratoid/rhabdoid tumor: short clinical description and insight into possible mechanism of the disease.Rhabdoid tumors: an initial clue to the role of chromatin remodeling in cancer.Rhabdoid tumors: clinical approaches and molecular targets for innovative therapy.Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.Molecular biology of pediatric brain tumors and impact on novel therapies.Biology and Treatment of Rhabdoid Tumor.Driver mutations of cancer epigenomes.Loss of CDKN1C in a Recurrent Atypical Teratoid/Rhabdoid Tumor.Loss of IGFBP7 expression and persistent AKT activation contribute to SMARCB1/Snf5-mediated tumorigenesis.Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway.

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P2860

Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss.

http://www.wikidata.org/entity/Q33922936

description

2005 nî lūn-bûn

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Genetic ablation of Cyclin D1 ...... mors resulting from Ini1 loss.

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Genetic ablation of Cyclin D1 ...... mors resulting from Ini1 loss.

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type

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Genetic ablation of Cyclin D1 ...... mors resulting from Ini1 loss.

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Genetic ablation of Cyclin D1 ...... mors resulting from Ini1 loss.

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Genetic ablation of Cyclin D1 ...... mors resulting from Ini1 loss.

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Genetic ablation of Cyclin D1 ...... mors resulting from Ini1 loss.

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Genetic ablation of Cyclin D1 ...... mors resulting from Ini1 loss.

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David Zagzag

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Ganjam V Kalpana

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Mary Tsikitis

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Winfried Edelman

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Zhikai Zhang

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P2860

Purification and biochemical heterogeneity of the mammalian SWI-SNF complex

Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers

A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export: implications for tumorigenesis

Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5.

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1

Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase

Expression of cyclin E and cyclin D1 in non-small cell lung cancers

Cycling to cancer with cyclin D1

The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors

Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase-independent mechanism

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10.1073/PNAS.0505300102

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16099835

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1189334

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