Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.
about
AIPL1, a protein implicated in Leber's congenital amaurosis, interacts with and aids in processing of farnesylated proteinsRas membrane targeting is essential for glucose signaling but not for viability in yeastInactivation of Icmt inhibits transformation by oncogenic K-Ras and B-RafPurified yeast protein farnesyltransferase is structurally and functionally similar to its mammalian counterpart.The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins.RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins.Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene productMutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins.SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes.Mating pheromones of the fission yeast Schizosaccharomyces pombe: purification and structural characterization of M-factor and isolation and analysis of two genes encoding the pheromoneA novel membrane-associated metalloprotease, Ste24p, is required for the first step of NH2-terminal processing of the yeast a-factor precursorCloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferaseFarnesyltransferase--new insights into the zinc-coordination sphere paradigm: evidence for a carboxylate-shift mechanism.Mutant farnesyltransferase beta subunit of Saccharomyces cerevisiae that can substitute for geranylgeranyltransferase type I beta subunit.Ras signaling in yeast.Identification of Ras farnesyltransferase inhibitors by microbial screening.Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharomyces pombe and Xenopus laevis.Fungal lipopeptide mating pheromones: a model system for the study of protein prenylationGenetic evidence for in vivo cross-specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiaeAcylation stabilizes a protease-resistant conformation of protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides.Endoproteolytic processing of a farnesylated peptide in vitro.Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activityControl of RAS mRNA level by the mevalonate pathway.RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis.A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acidIsoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents.Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway.Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast.Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe.Nucleotide sequence of the yeast STE14 gene, which encodes farnesylcysteine carboxyl methyltransferase, and demonstration of its essential role in a-factor export.Reconstitution of GTP-binding Sar1 protein function in ER to Golgi transportCharacterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe.Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I.Akr1p-dependent palmitoylation of Yck2p yeast casein kinase 1 is necessary and sufficient for plasma membrane targeting.A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues.The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis.
P2860
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P2860
Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.
description
1990 nî lūn-bûn
@nan
1990 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.
@ast
Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.
@en
type
label
Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.
@ast
Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.
@en
prefLabel
Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.
@ast
Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.
@en
P2093
P2860
P356
P1476
Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.
@en
P2093
C C Farnsworth
J A Glomset
L E Goodman
P2860
P304
P356
10.1073/PNAS.87.24.9665
P407
P577
1990-12-01T00:00:00Z