Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581
about
Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cellsEctopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemiaStructure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activityCBFbeta is critical for AML1-ETO and TEL-AML1 activity.Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis.Signaling in leukemia: which messenger to kill?Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1.The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-AblA murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin.Class III receptor tyrosine kinases: role in leukaemogenesis.THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover.Dissecting the molecular mechanism of chronic myelogenous leukemia using murine models.Studying the pathogenesis of BCR-ABL+ leukemia in mice.An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice.Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling.Targeting mutated tyrosine kinases in the therapy of myeloid leukaemias.Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage.Mechanisms controlling pathogenesis and survival of leukemic stem cells.Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease.Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cellsConstitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models.Fibroblast growth factor receptor and platelet-derived growth factor receptor abnormalities in eosinophilic myeloproliferative disorders.The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V.Critical role of the platelet-derived growth factor receptor (PDGFR) beta transmembrane domain in the TEL-PDGFRbeta cytosolic oncoprotein.The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo.Regulation of the Src homology 2-containing inositol 5-phosphatase SHIP1 in HIP1/PDGFbeta R-transformed cells.Tel induces a G1 arrest and suppresses Ras-induced transformation.Platelet-derived growth factors and their receptors in normal and malignant hematopoiesisRole of DHX33 in c-Myc-induced cancers.FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation.
P2860
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P2860
Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581
description
2000 nî lūn-bûn
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2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2000 թվականի փետրվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Fatal myeloproliferation, indu ...... on PDGFbetaR tyrosines 579/581
@ast
Fatal myeloproliferation, indu ...... on PDGFbetaR tyrosines 579/581
@en
type
label
Fatal myeloproliferation, indu ...... on PDGFbetaR tyrosines 579/581
@ast
Fatal myeloproliferation, indu ...... on PDGFbetaR tyrosines 579/581
@en
prefLabel
Fatal myeloproliferation, indu ...... on PDGFbetaR tyrosines 579/581
@ast
Fatal myeloproliferation, indu ...... on PDGFbetaR tyrosines 579/581
@en
P2093
P2860
P356
P1476
Fatal myeloproliferation, indu ...... on PDGFbetaR tyrosines 579/581
@en
P2093
D G Gilliland
D W Sternberg
I R Williams
M H Tomasson
R A Van Etten
R L Ilaria
P2860
P304
P356
10.1172/JCI8902
P407
P577
2000-02-01T00:00:00Z