Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581 - Test2 - elhamkhani - TriplyDB

Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581

Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581

http://www.wikidata.org/entity/Q33939204

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Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity CBFbeta is critical for AML1-ETO and TEL-AML1 activity.Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis.Signaling in leukemia: which messenger to kill?Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1.The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9 Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin.Class III receptor tyrosine kinases: role in leukaemogenesis.THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover.Dissecting the molecular mechanism of chronic myelogenous leukemia using murine models.Studying the pathogenesis of BCR-ABL+ leukemia in mice.An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice.Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling.Targeting mutated tyrosine kinases in the therapy of myeloid leukaemias.Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage.Mechanisms controlling pathogenesis and survival of leukemic stem cells.Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease.Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models.Fibroblast growth factor receptor and platelet-derived growth factor receptor abnormalities in eosinophilic myeloproliferative disorders.The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V.Critical role of the platelet-derived growth factor receptor (PDGFR) beta transmembrane domain in the TEL-PDGFRbeta cytosolic oncoprotein.The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo.Regulation of the Src homology 2-containing inositol 5-phosphatase SHIP1 in HIP1/PDGFbeta R-transformed cells.Tel induces a G1 arrest and suppresses Ras-induced transformation.Platelet-derived growth factors and their receptors in normal and malignant hematopoiesis Role of DHX33 in c-Myc-induced cancers.FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation.

P2860

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P2860

Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581

http://www.wikidata.org/entity/Q33939204

description

2000 nî lūn-bûn

@nan

2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի փետրվարին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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Fatal myeloproliferation, indu ...... on PDGFbetaR tyrosines 579/581

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Fatal myeloproliferation, indu ...... on PDGFbetaR tyrosines 579/581

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Fatal myeloproliferation, indu ...... on PDGFbetaR tyrosines 579/581

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Fatal myeloproliferation, indu ...... on PDGFbetaR tyrosines 579/581

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Fatal myeloproliferation, indu ...... on PDGFbetaR tyrosines 579/581

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Fatal myeloproliferation, indu ...... on PDGFbetaR tyrosines 579/581

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P2093

D Cain

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D G Gilliland

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D W Sternberg

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I R Williams

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J C Aster

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M Carroll

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M H Tomasson

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R A Van Etten

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R L Ilaria

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P2860

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases

Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

Signal transduction via platelet-derived growth factor receptors

Improved retroviral vectors for gene transfer and expression.

Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus.

Seed versus soil: the importance of the target cell for transgenic models of human leukemias.

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation.

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.

The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways.

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4

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105

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12632868

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10683371

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