Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters. - Test2 - elhamkhani - TriplyDB

Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.

Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.

http://www.wikidata.org/entity/Q33942993

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Inherited disorders of bilirubin clearance Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.How Does In Vivo Biliary Elimination of Drugs Change with Age? Evidence from In Vitro and Clinical Data Using a Systems Pharmacology Approach.Dosing in neonates: special considerations in physiology and trial design.Altered regulation of hepatic efflux transporters disrupts acetaminophen disposition in pediatric nonalcoholic steatohepatitis.Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver Developmental Regulation of Drug-Processing Genes in Livers of Germ-Free Mice Age-Specific Regulation of Drug-Processing Genes in Mouse Liver by Ligands of Xenobiotic-Sensing Transcription Factors.Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver The Promises of Quantitative Proteomics in Precision Medicine Lobular Distribution and Variability in Hepatic ATP Binding Cassette Protein B1 (ABCB1, P-gp): Ontogenetic Differences and Potential for Toxicity.Ethics review of pediatric multi-center drug trials.Assessment of health risks resulting from early-life exposures: Are current chemical toxicity testing protocols and risk assessment methods adequate?Ontogeny of Hepatic Drug Transporters and Relevance to Drugs Used in Pediatrics.Physiologically Based Pharmacokinetic Modeling in Pediatric Oncology Drug Development.Drug transporter gene expression in human colorectal tissue and cell lines: modulation with antiretrovirals for microbicide optimization.Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy.Causes and Consequences of Variability in Drug Transporter Activity in Pediatric Drug Therapy.Oral drug absorption in pediatrics: the intestinal wall, its developmental changes and current tools for predictions.The molecular basis of jaundice: An old symptom revisited.Trafficking and other regulatory mechanisms for organic anion transporting polypeptides and organic anion transporters that modulate cellular drug and xenobiotic influx and that are dysregulated in disease.Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.Long-term administration of tenofovir or emtricitabine to pregnant rats; effect on Abcb1a, Abcb1b and Abcg2 expression in the placenta and in maternal and fetal organs.Use of microdose phenotyping to individualise dosing of patients.Editor's Highlight: Neonatal Activation of the Xenobiotic-Sensors PXR and CAR Results in Acute and Persistent Down-regulation of PPARα-Signaling in Mouse Liver.Bottom-up Meets Top-down: Complementary Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling for Regulatory Approval of a Dosing Algorithm of Valganciclovir in Very Young Children.RNA Sequencing Reveals Age and Species Differences of Constitutive Androstane Receptor-Targeted Drug-Processing Genes in the Liver.Membrane Transporters for Bilirubin and Its Conjugates: A Systematic Review.Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life.Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants.Tacrolimus dose requirements in paediatric renal allograft recipients are characterized by a biphasic course determined by age and bone maturation.Age dependence of spleen- and muscle-corrected hepatic signal enhancement on hepatobiliary phase gadoxetate MRI.Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1- and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions.

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P2860

Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.

http://www.wikidata.org/entity/Q33942993

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2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014年の論文

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Barbara A E de Koning

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Edwin Spaans

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J Steven Leeder

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Janneke N Samsom

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Johannes B van Goudoever

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Miriam G Mooij

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Richard B Kim

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Saskia N de Wildt

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Ute I Schwarz

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P2860

Analyzing real-time PCR data by the comparative C(T) method

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

Enterocytic CYP3A4 in a paediatric population: developmental changes and the effect of coeliac disease and cystic fibrosis

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues.

Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

Developmental pharmacology--drug disposition, action, and therapy in infants and children.

Developmental expression of canalicular transporter genes in human liver.

Pharmacokinetics and metabolism of oral midazolam in preterm infants.

Multidrug resistance gene (P-glycoprotein) expression in the human fetus.

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