Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies. - Test2 - elhamkhani - TriplyDB

Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies.

Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies.

http://www.wikidata.org/entity/Q33951935

about

Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases.Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes.Paclitaxel improves outcome from traumatic brain injury.Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer's Disease and Related Tauopathies Intracellular and extracellular microtubule associated protein tau as a therapeutic target in Alzheimer disease and other tauopathies.Aminochrome Toxicity is Mediated by Inhibition of Microtubules Polymerization Through the Formation of Adducts with Tubulin.Do Cancer Drugs Counteract Neurodegeneration? Repurposing for Alzheimer's Disease.Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies.Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs.Potential Role of Microtubule Stabilizing Agents in Neurodevelopmental Disorders.Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine.Stim2-Eb3 Association and Morphology of Dendritic Spines in Hippocampal Neurons.Organic synthesis in the Smith Group: a personal selection of a dozen lessons learned at the University of Pennsylvania.Waves transmission and amplification in an electrical model of microtubules.Repositioning Microtubule Stabilizing Drugs for Brain Disorders

P2860

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P2860

Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies.

http://www.wikidata.org/entity/Q33951935

description

2014 nî lūn-bûn

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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2014 թվականի հուլիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Brain-penetrant, orally bioava ...... sease and related tauopathies.

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Brain-penetrant, orally bioava ...... sease and related tauopathies.

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type

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Brain-penetrant, orally bioava ...... sease and related tauopathies.

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Brain-penetrant, orally bioava ...... sease and related tauopathies.

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Brain-penetrant, orally bioava ...... sease and related tauopathies.

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Brain-penetrant, orally bioava ...... sease and related tauopathies.

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Journal of Medicinal Chemistry

P1476

Brain-penetrant, orally bioava ...... sease and related tauopathies.

@en

P2093

Adam T Hoye

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Amos B Smith

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Anne-Sophie Cornec

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Bryant Gay

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Edward Hyde

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John Q Trojanowski

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Kurt R Brunden

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Michael J James

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Virginia M-Y Lee

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Yuemang Yao

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P2860

Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

Axonal transport defects: a common theme in neurodegenerative diseases

Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies

Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency

The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.

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6116-6127

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scholarly article

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10.1021/JM5005623

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14

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57

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Carlo Ballatore

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263708605

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24992153

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Alzheimer's disease

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4111403

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