Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency - Test2 - elhamkhani - TriplyDB

Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency

Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency

http://www.wikidata.org/entity/Q33959699

about

Regulation of Bim in Health and Disease Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.Myt3 suppression sensitizes islet cells to high glucose-induced cell death via Bim induction.Pancreatic β-Cell Death due to Pdx-1 Deficiency Requires Multi-BH Domain Protein Bax but Not Bak.BH3-Only protein bmf is required for the maintenance of glucose homeostasis in an in vivo model of HNF1α-MODY diabetes.IER3IP1 deficiency leads to increased β-cell death and decreased β-cell proliferation.The esoteric roles of Bcl-2 family proteins in glucose homeostasis and cell survival.

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P2860

Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency

http://www.wikidata.org/entity/Q33959699

description

2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

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name

Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency

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Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency

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type

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Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency

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Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency

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Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency

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Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency

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Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency

@en

P2093

Changzheng Wang

http://www.w3.org/2001/XMLSchema#string

Decheng Ren

http://www.w3.org/2001/XMLSchema#string

Emily H Cheng

http://www.w3.org/2001/XMLSchema#string

Graeme I Bell

http://www.w3.org/2001/XMLSchema#string

Honggang Ye

http://www.w3.org/2001/XMLSchema#string

Juan Sun

http://www.w3.org/2001/XMLSchema#string

Kenneth S Polonsky

http://www.w3.org/2001/XMLSchema#string

Liqun Mao

http://www.w3.org/2001/XMLSchema#string

P2860

Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome

Increased islet apoptosis in Pdx1+/- mice

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency.

Limitations in the Use of Fluorescein Diacetate/Propidium Iodide (FDA/PI) and Cell Permeable Nucleic Acid Stains for Viability Measurements of Isolated Islets of Langerhans

Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes

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2744-2750

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scholarly article

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10.2337/DB13-1513

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8

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63

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2014-03-21T00:00:00Z

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261033963

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24658302

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