Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice.
about
Highlight: BRCA1 and BRCA2 proteins in breast cancerAssociation of BRCA1 mutations with occult primary ovarian insufficiency: a possible explanation for the link between infertility and breast/ovarian cancer risksRole of BRCA gene dysfunction in breast and ovarian cancer predisposition.Are Trp53 rescue of Brca1 embryonic lethality and Trp53/Brca1 breast cancer association related?Association of BRCA1 Mutations with Impaired Ovarian Reserve: Connection Between Infertility and Breast/Ovarian Cancer RiskPositional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in miceCombining RNA and protein profiling data with network interactions identifies genes associated with spermatogenesis in mouse and human.Tumor suppressor p53 is required to modulate BRCA1 expression.Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear fociMale fertility defect associated with disrupted BRCA1-PALB2 interaction in miceCollaboration of Brca1 and Chk2 in tumorigenesis.BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability.Abnormality of the DNA double-strand-break checkpoint/repair genes, ATM, BRCA1 and TP53, in breast cancer is related to tumour gradeSenataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencingDNA mismatch repair and infertilityTumorigenesis in mice carrying a truncating Brca1 mutationA molecular portrait of Arabidopsis meiosis.BRCA1 deficient mouse models to study pathogenesis and therapy of triple negative breast cancer.Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects.The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapyRecognition of DNA double strand breaks by the BRCA1 tumor suppressor network.Preclinical mouse models for BRCA1-associated breast cancer.LMTK2 and PARP-2 gene polymorphism and azoospermia secondary to meiotic arrest.Human ovarian tissue cortex surrounding benign and malignant lesions.The origins and evolution of genetic disease risk in modern humans.Midgestation lethality in mice deficient for the RecA-related gene, Rad51d/Rad51l3.Non-coding RNAs in Mammary Gland Development and Disease.BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein.c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.Brca1 inactivation induces p27(Kip1)-dependent cell cycle arrest and delayed development in the mouse mammary gland.Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice.Identification of a novel transcriptional repressor element located in the first intron of the human BRCA1 gene.BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene.
P2860
Q24307401-563DE81C-90A2-425A-B995-4198FCFDEB42Q24621546-22F5A432-DC37-4DEA-BD46-F71CCBD7437DQ24800677-3B6D0E64-2BFD-44ED-88B2-7BD92793A46AQ24802238-EFB7FF50-AF89-42F6-832F-E666FE256C95Q28396126-AE50F6A2-95E5-42D9-8652-B602A95F3889Q28512598-AD041397-9015-4E86-B346-7000BAB24C03Q30885504-AAB2ED68-E0F7-4720-AF7D-6E4C44415B05Q33965851-26412559-3BB4-4447-B458-6875A116232AQ33968470-C2D76F13-3082-4E6F-BCDC-B03EC555F01DQ34107377-74E87637-121B-400F-BAF8-82B03C7072CEQ34142447-FD5CF90C-6FD2-4257-9D62-D4B8453560A2Q34539782-3B3F022F-4E02-4C64-835F-EB618640F65DQ34547808-2248AD1B-9114-4488-9BAE-9F362BEAB045Q34672035-607E020A-D685-4069-B1C9-3239055E30BCQ34814254-76131687-10C4-4F35-9643-9837D8139DFDQ35109897-BCB2FC18-A117-410C-886B-A74D1CC342B4Q35625730-463A3445-4A6F-4567-A201-2D0A0045F83AQ36406519-B3FE5FD4-A5CE-42A3-9275-20771DE395ADQ36602578-5BAE105E-75AB-434A-9A24-15F2D1921DB2Q36689932-D0EA37A3-C77F-409F-BF84-349FAEE6BDD5Q37120275-157ACC39-4E04-4FB9-BDF0-4D94769E01D3Q37424070-DCE44755-A923-441D-9737-7BDA3B217E2EQ37459212-099FA336-1FDC-4418-AAF4-8B40545431F5Q37699285-56C44A52-DAF6-48F9-A3C5-967C79622799Q37791205-116B0ECA-7CDE-4566-BBBF-E2C207AC7B70Q38314351-66861FA4-4E5F-43B7-AC92-E560D1410F07Q38667231-240F3CDA-C399-4A58-94AD-AE7BA51D77E0Q39506911-24B0160D-22E3-46E3-BE92-7E49979AC6B2Q40025608-6044B33B-7CA4-4139-AAE9-F64639659D0EQ40543164-6C0BB8F2-E72F-465E-B7DF-1605DD76FC18Q40858473-91D52566-BDF0-431F-8E1C-B3680473FD3AQ42647919-781724D4-4547-4A76-8351-5CC01DFBF0E0Q52537650-E0E42F4C-07E4-40BE-B299-6FB1C21909E3
P2860
Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice.
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Growth retardation, DNA repair ...... nesis in BRCA1-deficient mice.
@ast
Growth retardation, DNA repair ...... nesis in BRCA1-deficient mice.
@en
type
label
Growth retardation, DNA repair ...... nesis in BRCA1-deficient mice.
@ast
Growth retardation, DNA repair ...... nesis in BRCA1-deficient mice.
@en
prefLabel
Growth retardation, DNA repair ...... nesis in BRCA1-deficient mice.
@ast
Growth retardation, DNA repair ...... nesis in BRCA1-deficient mice.
@en
P2093
P2860
P356
P1476
Growth retardation, DNA repair ...... nesis in BRCA1-deficient mice.
@en
P2093
A V Avrutskaya
B H Koller
D C Backlund
S A Leadon
V L Cressman
P2860
P304
P356
10.1128/MCB.19.10.7061
P407
P577
1999-10-01T00:00:00Z