Teaching old receptors new tricks: biasing seven-transmembrane receptors. - Test2 - elhamkhani - TriplyDB

Teaching old receptors new tricks: biasing seven-transmembrane receptors.

Teaching old receptors new tricks: biasing seven-transmembrane receptors.

http://www.wikidata.org/entity/Q33985759

about

Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRs PTH receptor-1 signalling-mechanistic insights and therapeutic prospects Physiology of the orexinergic/hypocretinergic system: a revisit in 2012 Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system Tissue factor, protease activated receptors and pathologic heart remodelling Structure determination of membrane proteins by nuclear magnetic resonance spectroscopy Signaling effectors underlying pathologic growth and remodeling of the heart Targeting G protein coupled receptor-related pathways as emerging molecular therapies Heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor in normal and neoplastic hematopoiesis G-protein-coupled receptors targeting: the allosteric approach Constitutively active rhodopsin and retinal disease Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions.Structure of the chemokine receptor CXCR1 in phospholipid bilayers Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol Nanobody stabilization of G protein-coupled receptor conformational states.Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1 The circadian clock in cancer development and therapy Expression and membrane topology of Anopheles gambiae odorant receptors in lepidopteran insect cells Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavir Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)Development and evaluation of small peptidomimetic ligands to protease-activated receptor-2 (PAR2) through the use of lipid tethering Eukaryotic translation initiation factor 3, subunit a, regulates the extracellular signal-regulated kinase pathway Agonist-directed desensitization of the β2-adrenergic receptor CC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10 Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins.Modelling three-dimensional protein structures for applications in drug design.Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity, and learning deficits in a fragile X model.A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells Simulations of biased agonists in the β(2) adrenergic receptor with accelerated molecular dynamics.Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of β-arrestin complexes and endocytic targeting on the membrane mobility of neuropeptide Y receptors CXCL12 and [N33A]CXCL12 in 5637 and HeLa cells: regulating HER1 phosphorylation via calmodulin/calcineurin.Divergent label-free cell phenotypic pharmacology of ligands at the overexpressed β₂-adrenergic receptors.Novel insights into G protein and G protein-coupled receptor signaling in cancer Emerging concepts and approaches for chemokine-receptor drug discovery.Clozapine acts as an agonist at serotonin 2A receptors to counter MK-801-induced behaviors through a βarrestin2-independent activation of Akt Angiotensin receptor type 1 and endothelin receptor type A on immune cells mediate migration and the expression of IL-8 and CCL18 when stimulated by autoantibodies from systemic sclerosis patients β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation.

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P2860

Teaching old receptors new tricks: biasing seven-transmembrane receptors.

http://www.wikidata.org/entity/Q33985759

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Teaching old receptors new tricks: biasing seven-transmembrane receptors.

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Teaching old receptors new tricks: biasing seven-transmembrane receptors.

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type

label

Teaching old receptors new tricks: biasing seven-transmembrane receptors.

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Teaching old receptors new tricks: biasing seven-transmembrane receptors.

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Teaching old receptors new tricks: biasing seven-transmembrane receptors.

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Teaching old receptors new tricks: biasing seven-transmembrane receptors.

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Nature Reviews Drug Discovery

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Teaching old receptors new tricks: biasing seven-transmembrane receptors.

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P2093

Keshava Rajagopal

http://www.w3.org/2001/XMLSchema#string

Robert J Lefkowitz

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Sudarshan Rajagopal

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P2860

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

Novel function of beta-arrestin2 in the nucleus of mature spermatozoa

A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription

beta-Arrestin: a protein that regulates beta-adrenergic receptor function

A beta-arrestin 2 signaling complex mediates lithium action on behavior

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

Functional specialization of beta-arrestin interactions revealed by proteomic analysis

beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation

Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis

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373-386

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10.1038/NRD3024

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5

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9

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1019247687

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transmembrane protein

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2902265

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