Use of transposon Tn5367 mutagenesis and a nitroimidazopyran-based selection system to demonstrate a requirement for fbiA and fbiB in coenzyme F(420) biosynthesis by Mycobacterium bovis BCG
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Metabolic engineering of cofactor F420 production in Mycobacterium smegmatisDemonstration that fbiC is required by Mycobacterium bovis BCG for coenzyme F(420) and FO biosynthesisPA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO releaseIdentification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosisInsights into the pharmacokinetic properties of antitubercular drugs.Mycobacterial gene cuvA is required for optimal nutrient utilization and virulencePreclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models.The chemical biology of new drugs in the development for tuberculosis.F420H2-dependent degradation of aflatoxin and other furanocoumarins is widespread throughout the actinomycetalesCritical role of 7,8-didemethyl-8-hydroxy-5-deazariboflavin for photoreactivation in Chlamydomonas reinhardtii.Mycobacterium leprae is naturally resistant to PA-824Impact of Fgd1 and ddn diversity in Mycobacterium tuberculosis complex on in vitro susceptibility to PA-824.Current development and future prospects in chemotherapy of tuberculosisMutations in genes for the F420 biosynthetic pathway and a nitroreductase enzyme are the primary resistance determinants in spontaneous in vitro-selected PA-824-resistant mutants of Mycobacterium tuberculosisImportance of the genetic diversity within the Mycobacterium tuberculosis complex for the development of novel antibiotics and diagnostic tests of drug resistanceMycobacterium marinum mmar_2318 and mmar_2319 are Responsible for Lipooligosaccharide Biosynthesis and Virulence Toward DictyosteliumEfficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis.Physiology, Biochemistry, and Applications of F420- and Fo-Dependent Redox Reactions.In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxideF420H2 Is Required for Phthiocerol Dimycocerosate Synthesis in Mycobacteria.Conversion of NO2 to NO by reduced coenzyme F420 protects mycobacteria from nitrosative damage.New drugs against tuberculosis: problems, progress, and evaluation of agents in clinical development.Mechanism of action of 5-nitrothiophenes against Mycobacterium tuberculosis.Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) from Mycobacterium tuberculosis.Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles.Elongation of the Poly-γ-glutamate Tail of F420 Requires Both Domains of the F420:γ-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis.The methanogenic redox cofactor F420 is widely synthesized by aerobic soil bacteria.Maximizing bactericidal activity with combinations of bioreduced drugs.3D-QSAR and cell wall permeability of antitubercular nitroimidazoles against Mycobacterium tuberculosis.Evolution of Phenotypic and Molecular Drug Susceptibility Testing.Novel Pyrimidines as Antitubercular Agents.Role of the Mycobacterium marinum ESX-1 Secretion System in Sliding Motility and Biofilm Formation.Challenging the Drug-Likeness Dogma for New Drug Discovery in Tuberculosis
P2860
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P2860
Use of transposon Tn5367 mutagenesis and a nitroimidazopyran-based selection system to demonstrate a requirement for fbiA and fbiB in coenzyme F(420) biosynthesis by Mycobacterium bovis BCG
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Use of transposon Tn5367 mutag ...... sis by Mycobacterium bovis BCG
@ast
Use of transposon Tn5367 mutag ...... sis by Mycobacterium bovis BCG
@en
type
label
Use of transposon Tn5367 mutag ...... sis by Mycobacterium bovis BCG
@ast
Use of transposon Tn5367 mutag ...... sis by Mycobacterium bovis BCG
@en
prefLabel
Use of transposon Tn5367 mutag ...... sis by Mycobacterium bovis BCG
@ast
Use of transposon Tn5367 mutag ...... sis by Mycobacterium bovis BCG
@en
P2093
P2860
P1476
Use of transposon Tn5367 mutag ...... sis by Mycobacterium bovis BCG
@en
P2093
P2860
P304
P356
10.1128/JB.183.24.7058-7066.2001
P407
P577
2001-12-01T00:00:00Z