Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.
about
Inhibition of STAT5: a therapeutic option in BCR-ABL1-driven leukemiaMitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiationInvestigation of the effective action distance between hematopoietic stem/progenitor cells and human adipose-derived stem cells during their in vitro co-culture.Cancer stem cells: a stride towards cancer cure?Extensive gene-specific translational reprogramming in a model of B cell differentiation and Abl-dependent transformationActivation of the vascular niche supports leukemic progression and resistance to chemotherapyThe Ph-positive and Ph-negative myeloproliferative neoplasms: some topical pre-clinical and clinical issues.Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formationELMO1 is upregulated in AML CD34+ stem/progenitor cells, mediates chemotaxis and predicts poor prognosis in normal karyotype AML.High VLA-4 expression is associated with adverse outcome and distinct gene expression changes in childhood B-cell precursor acute lymphoblastic leukemia at first relapse.Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia.Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells.Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors.Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARα degradation.PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells.Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cellsChronic myeloid leukemia stem cells and developing therapies.Rho GTPases modulate malignant transformation of tumor cells.New alternative splicing BCR/ABL-OOF shows an oncogenic role by lack of inhibition of BCR GTPase activity and an increased of persistence of Rac activation in chronic myeloid leukemia.Cellular and Molecular Networks in Chronic Myeloid Leukemia: The Leukemic Stem, Progenitor and Stromal Cell Interplay.A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motilityPhosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.Pretreatment with IFN-α increases resistance to imatinib mesylate in patients with chronic myelocytic leukemiaWnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia.Leukemic spleen cells are more potent than bone marrow-derived cells in a transgenic mouse model of CML
P2860
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P2860
Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.
@ast
Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.
@en
type
label
Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.
@ast
Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.
@en
prefLabel
Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.
@ast
Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.
@en
P2093
P2860
P1433
P1476
Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.
@en
P2093
Amitava Sengupta
David A Williams
Jorden Arnett
Jose A Cancelas
Susan Dunn
P2860
P356
10.1182/BLOOD-2009-10-247437
P407
P577
2010-04-20T00:00:00Z