MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II
about
Mutations in myosin light chain kinase cause familial aortic dissectionsTreatment guidelines for thoracic aortic aneurysms and dissections based on the underlying causative geneSuccesses and challenges of using whole exome sequencing to identify novel genes underlying an inherited predisposition for thoracic aortic aneurysms and acute aortic dissectionsThe role of mechanotransduction on vascular smooth muscle myocytes' [corrected] cytoskeleton and contractile functionIncomplete segregation of MYH11 variants with thoracic aortic aneurysms and dissections and patent ductus arteriosus.Smooth muscle phenotypic modulation is an early event in aortic aneurysmsGenome screen to detect linkage to common susceptibility genes for intracranial and aortic aneurysmsPharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted Transforming Growth Factor-β Signaling Despite Compromised Extracellular Matrix Properties.Rare de novo copy number variants in patients with congenital pulmonary atresia.Overexpression of smooth muscle myosin heavy chain leads to activation of the unfolded protein response and autophagic turnover of thick filament-associated proteins in vascular smooth muscle cellsEmbryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical applicationFibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progressionThe role of the renin-angiotensin system in aortic aneurysmal diseases.Recurrent chromosome 16p13.1 duplications are a risk factor for aortic dissections.Impaired vascular contractility and aortic wall degeneration in fibulin-4 deficient mice: effect of angiotensin II type 1 (AT1) receptor blockade.The genetic basis of aortic aneurysmSerum proteomic signature of human chagasic patients for the identification of novel potential protein biomarkers of disease.TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections.Rare copy number variants disrupt genes regulating vascular smooth muscle cell adhesion and contractility in sporadic thoracic aortic aneurysms and dissectionsEpigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms.Cyclooxygenase-2 inhibition attenuates abdominal aortic aneurysm progression in hyperlipidemic mice.Causes and histopathology of ascending aortic disease in children and young adults.Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections.Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice.Three novel mutations in the ACTA2 gene in German patients with thoracic aortic aneurysms and dissections.Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.Gene panel sequencing in heritable thoracic aortic disorders and related entities - results of comprehensive testing in a cohort of 264 patients.BRG1 overexpression in smooth muscle cells promotes the development of thoracic aortic dissection.Novel MYH11 and ACTA2 mutations reveal a role for enhanced TGFβ signaling in FTAAD.A roadmap to investigate the genetic basis of bicuspid aortic valve and its complications: insights from the International BAVCon (Bicuspid Aortic Valve Consortium).Differences in genetic signaling, and not mechanical properties of the wall, are linked to ascending aortic aneurysms in fibulin-4 knockout miceFirst genetic analysis of aneurysm genes in familial and sporadic abdominal aortic aneurysm.Aortic Disease Presentation and Outcome Associated With ACTA2 Mutations.Matrix-dependent perturbation of TGFβ signaling and diseaseEffects of Advancing Gestation and Non-Caucasian Race on Ductus Arteriosus Gene Expression.Diabetes and reduced risk for thoracic aortic aneurysms and dissections: a nationwide case-control studyGenetic dissection of marfan syndrome and related connective tissue disorders: an update 2012.Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in MiceAn essential requirement for β1 integrin in the assembly of extracellular matrix proteins within the vascular wall.A deleterious MYH11 mutation causing familial thoracic aortic dissection
P2860
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P2860
MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
MYH11 mutations result in a di ...... th factor 1 and angiotensin II
@ast
MYH11 mutations result in a di ...... th factor 1 and angiotensin II
@en
MYH11 mutations result in a di ...... th factor 1 and angiotensin II
@nl
type
label
MYH11 mutations result in a di ...... th factor 1 and angiotensin II
@ast
MYH11 mutations result in a di ...... th factor 1 and angiotensin II
@en
MYH11 mutations result in a di ...... th factor 1 and angiotensin II
@nl
prefLabel
MYH11 mutations result in a di ...... th factor 1 and angiotensin II
@ast
MYH11 mutations result in a di ...... th factor 1 and angiotensin II
@en
MYH11 mutations result in a di ...... th factor 1 and angiotensin II
@nl
P2093
P2860
P50
P356
P1476
MYH11 mutations result in a di ...... th factor 1 and angiotensin II
@en
P2093
A J Marian
Anthony L Estrera
Caroline Presley
Christina L Papke
Dianna M Milewicz
Dongchuan Guo
G Wesley Vick
Hariyadarshi Pannu
Hazim J Safi
Steve Scherer
P2860
P304
P356
10.1093/HMG/DDM201
P577
2007-07-31T00:00:00Z