An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing. - Test2 - elhamkhani - TriplyDB

An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.

An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.

http://www.wikidata.org/entity/Q34010440

about

BK channels: multiple sensors, one activation gate Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation BK Channels in the Central Nervous System.CRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis.K(+) channelepsy: progress in the neurobiology of potassium channels and epilepsy.A BK (Slo1) channel journey from molecule to physiology.Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy.Structural determinants of phosphatidylinositol 4,5-bisphosphate (PIP2) regulation of BK channel activity through the RCK1 Ca2+ coordination site.Emerging role of the KCNT1 Slack channel in intellectual disability.The regulation of BK channel activity by pre- and post-translational modifications.BK channel activation: structural and functional insights KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine Ion sensing in the RCK1 domain of BK channels.Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channel Modulation of BK channel gating by the ß2 subunit involves both membrane-spanning and cytoplasmic domains of Slo1.Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus.Mg(2+) binding to open and closed states can activate BK channels provided that the voltage sensors are elevated The contribution of RCK domains to human BK channel allosteric activation Coupling of voltage-sensors to the channel pore: a comparative view Single Channel Recordings Reveal Differential β2 Subunit Modulations Between Mammalian and Drosophila BKCa(β2) Channels.Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels.The cytosolic GH loop regulates the phosphatidylinositol 4,5-bisphosphate-induced gating kinetics of Kir2 channels.Interaction between residues in the Mg2+-binding site regulates BK channel activation State-dependent FRET reports calcium- and voltage-dependent gating-ring motions in BK channels Conopeptide Vt3.1 preferentially inhibits BK potassium channels containing β4 subunits via electrostatic interactions.BK-type calcium-activated potassium channels: coupling of metal ions and voltage sensing.Targeting BK (big potassium) channels in epilepsy.K(+) channels: function-structural overview.BKCa channel dysfunction in neurological diseases Potassium Channels in Epilepsy.Molecular Determinants of BK Channel Functional Diversity and Functioning.International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels.A portion of inhibitory neurons in human temporal lobe epilepsy are functionally upregulated: an endogenous mechanism for seizure termination.Allosteric-activation mechanism of BK channel gating ring triggered by calcium ions.Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels Presynaptic BK channels control transmitter release: physiological relevance and potential therapeutic implications.A less flexible BK channel opens more easily.In vivo treatment with the casein kinase 2 inhibitor 4,5,6,7- tetrabromotriazole augments the slow afterhyperpolarizing potential and prevents acute epileptiform activity.Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel.

P2860

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P2860

An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.

http://www.wikidata.org/entity/Q34010440

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

An epilepsy/dyskinesia-associa ...... by potentiating Ca2+ sensing.

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An epilepsy/dyskinesia-associa ...... by potentiating Ca2+ sensing.

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An epilepsy/dyskinesia-associa ...... by potentiating Ca2+ sensing.

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An epilepsy/dyskinesia-associa ...... by potentiating Ca2+ sensing.

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An epilepsy/dyskinesia-associa ...... by potentiating Ca2+ sensing.

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An epilepsy/dyskinesia-associa ...... by potentiating Ca2+ sensing.

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An epilepsy/dyskinesia-associa ...... by potentiating Ca2+ sensing.

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An epilepsy/dyskinesia-associa ...... by potentiating Ca2+ sensing.

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An epilepsy/dyskinesia-associa ...... by potentiating Ca2+ sensing.

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Guohui Zhang

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Jianmin Cui

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P2860

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

A novel calcium-sensing domain in the BK channel.

Gating mechanism of BK (Slo1) channels: so near, yet so far

Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel

Crystal structure and mechanism of a calcium-gated potassium channel

Structural basis for modulation and agonist specificity of HCN pacemaker channels

Comparative protein modelling by satisfaction of spatial restraints

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels

The sodium-activated potassium channel is encoded by a member of the Slo gene family

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Gayathri Krishnamoorthy

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