A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent
about
The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race, and sexPharmGKB summary: very important pharmacogene information for cytochrome P-450, family 2, subfamily A, polypeptide 6Relationship between amounts of daily cigarette consumption and abdominal obesity moderated by CYP2A6 genotypes in Chinese male current smokers.A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo.Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphismsPlasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age.Associations of CYP2A6 genotype with smoking behaviors in southern China.A pilot clinical trial of varenicline for smoking cessation in black smokers.Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6.Ancestral-derived effects on the mutational landscape of laryngeal cancer.A clinical trial to examine disparities in quitting between African-American and White adult smokers: Design, accrual, and baseline characteristics.Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: impact of CYP2A6 genetic variation and enzymatic activityAssociation of nicotine metabolite ratio and CYP2A6 genotype with smoking cessation treatment in African-American light smokersNicotine dependence pharmacogenetics: role of genetic variation in nicotine-metabolizing enzymesGenetic determinants of CYP2A6 activity across racial/ethnic groups with different risks of lung cancer and effect on their smoking intensityCYP2A6 polymorphisms and risk for tobacco-related cancers.Novel CYP2A6 variants identified in African Americans are associated with slow nicotine metabolism in vitro and in vivo.Systematic review of the relationship between the 3-hydroxycotinine/cotinine ratio and cigarette dependence.Polymorphic metabolism by functional alterations of human cytochrome P450 enzymes.Distribution of polymorphic variants of CYP2A6 and their involvement in nicotine addiction.CYP2A6 genotyping methods and strategies using real-time and end point PCR platforms.New CYP2A6 gene deletion and conversion variants in a population of Black African descent.Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences.Variation in CYP2A6 Activity and Personalized Medicine.Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.Metabolism of 7-ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants.
P2860
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P2860
A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A novel CYP2A6 allele, CYP2A6* ...... ation of Black-African descent
@ast
A novel CYP2A6 allele, CYP2A6* ...... ation of Black-African descent
@en
A novel CYP2A6 allele, CYP2A6* ...... ation of Black-African descent
@nl
type
label
A novel CYP2A6 allele, CYP2A6* ...... ation of Black-African descent
@ast
A novel CYP2A6 allele, CYP2A6* ...... ation of Black-African descent
@en
A novel CYP2A6 allele, CYP2A6* ...... ation of Black-African descent
@nl
prefLabel
A novel CYP2A6 allele, CYP2A6* ...... ation of Black-African descent
@ast
A novel CYP2A6 allele, CYP2A6* ...... ation of Black-African descent
@en
A novel CYP2A6 allele, CYP2A6* ...... ation of Black-African descent
@nl
P2093
P2860
P1476
A novel CYP2A6 allele, CYP2A6* ...... ation of Black-African descent
@en
P2093
Elizabeth M J Gillam
Jill C Mwenifumbo
Rachel F Tyndale
P2860
P356
10.1097/FPC.0B013E3282F3606E
P577
2008-01-01T00:00:00Z