Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells.
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Rho kinase proteins--pleiotropic modulators of cell survival and apoptosisRhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo.ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency.The propensity for tumorigenesis in human induced pluripotent stem cells is related with genomic instability.Gankyrin gene deletion followed by proteomic analysis: insight into the roles of Gankyrin in tumorigenesis and metastasisCharacterization of the binding interaction between the oncoprotein gankyrin and a grafted S6 ATPase.Gankyrin is a predictive and oncogenic factor in well-differentiated and dedifferentiated liposarcoma.The oncoprotein p28GANK establishes a positive feedback loop in β-catenin signaling.Intracellular signaling and hepatocellular carcinoma.Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver.Up-regulated oncoprotein P28GANK correlates with proliferation and poor prognosis of human glioma.Synthetic Proteins Potently and Selectively Bind the Oncoprotein Gankyrin, Modulate Its Interaction with S6 ATPase, and Suppress Gankyrin/MDM2-Dependent Ubiquitination of p53.RhoGDIα suppresses self-renewal and tumorigenesis of glioma stem cells.Depletion of pre-mRNA splicing factor Cdc5L inhibits mitotic progression and triggers mitotic catastropheGankyrin sustains PI3K/GSK-3β/β-catenin signal activation and promotes colorectal cancer aggressiveness and progression.Gankyrin promotes epithelial-mesenchymal transition and metastasis in NSCLC through forming a closed circle with IL-6/ STAT3 and TGF-β/SMAD3 signaling pathwayActivation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cellsRegulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.Gankyrin regulates cell signaling network.Gankyrin facilitates follicle-stimulating hormone-driven ovarian cancer cell proliferation through the PI3K/AKT/HIF-1α/cyclin D1 pathway.Discovery of multiple interacting partners of gankyrin, a proteasomal chaperone and an oncoprotein--evidence for a common hot spot site at the interface and its functional relevance.Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer.Rho GTPases and cancer.Gankyrin promotes breast cancer cell metastasis by regulating Rac1 activity.p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways.The oncoprotein gankyrin promotes the development of colitis-associated cancer through activation of STAT3.Resurfaced shape complementary proteins that selectively bind the oncoprotein gankyrin.Association of gankyrin and stemness factor expression in human colorectal cancer.Gankyrin: a novel promising therapeutic target for hepatocellular carcinoma.Crosstalk of Ras and Rho: activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models.Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability.
P2860
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P2860
Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells.
description
2010 nî lūn-bûn
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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Gankyrin plays an essential ro ...... CK pathway in mammalian cells.
@ast
Gankyrin plays an essential ro ...... CK pathway in mammalian cells.
@en
Gankyrin plays an essential ro ...... CK pathway in mammalian cells.
@nl
type
label
Gankyrin plays an essential ro ...... CK pathway in mammalian cells.
@ast
Gankyrin plays an essential ro ...... CK pathway in mammalian cells.
@en
Gankyrin plays an essential ro ...... CK pathway in mammalian cells.
@nl
prefLabel
Gankyrin plays an essential ro ...... CK pathway in mammalian cells.
@ast
Gankyrin plays an essential ro ...... CK pathway in mammalian cells.
@en
Gankyrin plays an essential ro ...... CK pathway in mammalian cells.
@nl
P2093
P2860
P356
P1476
Gankyrin plays an essential ro ...... CK pathway in mammalian cells.
@en
P2093
Ai-Ling Li
Bao-Feng Jin
Bing Liang
Hai-Ying Zhang
Hui-Yan Li
Jiang-Hong Man
Wei-Hua Li
P2860
P304
P356
10.1172/JCI42542
P407
P577
2010-07-12T00:00:00Z