Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome. - Test2 - elhamkhani - TriplyDB

Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome.

Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome.

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Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling Modeling Kidney Disease with iPS Cells G-protein Coupled Receptor Signaling in Pluripotent Stem Cell-derived Cardiovascular Cells: Implications for Disease Modeling Induced Pluripotency and Gene Editing in Disease Modelling: Perspectives and Challenges Cardiovascular Disease Modeling Using Patient-Specific Induced Pluripotent Stem Cells Translation of Human-Induced Pluripotent Stem Cells: From Clinical Trial in a Dish to Precision Medicine Molecular pathogenesis of long QT syndrome type 2 Inherited heart disease - what can we expect from the second decade of human iPS cell research?Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes Evaluation of the cardiotoxicity of mitragynine and its analogues using human induced pluripotent stem cell-derived cardiomyocytes Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop.Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing Dual optical recordings for action potentials and calcium handling in induced pluripotent stem cell models of cardiac arrhythmias using genetically encoded fluorescent indicators The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia.Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes.Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes.Investigating human disease using stem cell models.iPCS Cell Modeling of Inherited Cardiac Arrhythmias.Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters.Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue.Comparing ESC and iPSC-Based Models for Human Genetic Disorders Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy.Genome-wide association studies and contribution to cardiovascular physiology Toward Personalized Medicine: Using Cardiomyocytes Differentiated From Urine-Derived Pluripotent Stem Cells to Recapitulate Electrophysiological Characteristics of Type 2 Long QT Syndrome Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells.Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform.Pluripotent stem cells as a platform for cardiac arrhythmia drug screening Cardiac disease modeling using induced pluripotent stem cell-derived human cardiomyocytes.New approaches to establish genetic causality.Cardiomyopathy in a dish: using human inducible pluripotent stem cells to model inherited cardiomyopathies.Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as a Model for Heart Development and Congenital Heart Disease.From iPSC towards cardiac tissue-a road under construction.Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs)Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function Concise Review: Measuring Physiological Responses of Human Pluripotent Stem Cell Derived Cardiomyocytes to Drugs and Disease.Human Induced Pluripotent Stem Cells as a Platform for Personalized and Precision Cardiovascular Medicine.

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Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome.

http://www.wikidata.org/entity/Q34038853

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2013 nî lūn-bûn

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2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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Isogenic human pluripotent ste ...... mutation in long-QT syndrome.

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Isogenic human pluripotent ste ...... mutation in long-QT syndrome.

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Isogenic human pluripotent ste ...... mutation in long-QT syndrome.

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Isogenic human pluripotent ste ...... mutation in long-QT syndrome.

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Isogenic human pluripotent ste ...... mutation in long-QT syndrome.

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Isogenic human pluripotent ste ...... mutation in long-QT syndrome.

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Isogenic human pluripotent ste ...... mutation in long-QT syndrome.

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Isogenic human pluripotent ste ...... mutation in long-QT syndrome.

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Isogenic human pluripotent ste ...... mutation in long-QT syndrome.

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The EMBO Journal

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Isogenic human pluripotent ste ...... mutation in long-QT syndrome.

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Christian B Jung

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Leon G J Tertoolen

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Simona Casini

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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview

Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two-base encoding

Determinants of incomplete penetrance and variable expressivity in heritable cardiac arrhythmia syndromes

Induced pluripotent stem cell lines derived from human somatic cells

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

Transcriptome genetics using second generation sequencing in a Caucasian population

Common genetic variation and human traits

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

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10.1038/EMBOJ.2013.240

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