Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions. - Test2 - elhamkhani - TriplyDB

Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions.

Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions.

http://www.wikidata.org/entity/Q34047321

about

Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells.Targeted DNA methylation in pericentromeres with genome editing-based artificial DNA methyltransferase.Genetic and epigenetic control of gene expression by CRISPR-Cas systems.CRISPR Editing in Biological and Biomedical Investigation.Epigenome profiling and editing of neocortical progenitor cells during development.An all-in-one UniSam vector system for efficient gene activation CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes.Emerging mechanisms underlying astrogenesis in the developing mammalian brain.DEMETER plant DNA demethylase induces antiviral response by interferon signalling in animal cells.Regulation of tumour related genes by dynamic epigenetic alteration at enhancer regions in gastric epithelial cells infected by Epstein-Barr virus.Genome and Epigenome Editing in Mechanistic Studies of Human Aging and Aging-Related Disease.Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries.DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A.Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression.Inducible CRISPR genome-editing tool: classifications and future trends.A screening system to identify transcription factors that induce binding site-directed DNA demethylation.CRISPR-based strategies for studying regulatory elements and chromatin structure in mammalian gene control.TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells.Neuronal Dnmt1 Deficiency Attenuates Diet-Induced Obesity in Mice.Cancer induction and suppression with transcriptional control and epigenome editing technologies.A CRISPR reimagining: New twists and turns of CRISPR beyond the genome-engineering revolution.Controlled re-activation of epigenetically silenced Tet promoter-driven transgene expression by targeted demethylation.CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation.Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells.Updated summary of genome editing technology in human cultured cells linked to human genetics studies.Harnessing natural DNA modifying activities for editing of the genome and epigenome.Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species.Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain.Designing Epigenome Editors: Considerations of Biochemical and Locus Specificities.Applications of CRISPR/Cas9 in the Mammalian Central Nervous System.The past and presence of gene targeting: from chemicals and DNA via proteins to RNA.Cellular reprogramming technology for dissecting cancer epigenome in vivo.The CRISPR tool kit for genome editing and beyond.MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis.Induced PTF1a expression in pancreatic ductal adenocarcinoma cells activates acinar gene networks, reduces tumorigenic properties, and sensitizes cells to gemcitabine treatment.Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs A reference genome of the Chinese hamster based on a hybrid assembly strategy High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis

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Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions.

http://www.wikidata.org/entity/Q34047321

description

2016 nî lūn-bûn

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2016 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2016 թվականի օգոստոսին հրատարակված գիտական հոդված

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2016年の論文

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Nature Biotechnology

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Targeted DNA demethylation in ...... TET1 catalytic domain fusions.

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Atsuhiko Sakai

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Hideyuki Nakashima

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Hirofumi Noguchi

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Izuho Hatada

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Kazuhiko Nakabayashi

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Kenichiro Hata

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Kinichi Nakashima

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Mika Kimura

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Sumiyo Morita

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Takuro Horii

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P2860

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

RNA-guided human genome engineering via Cas9

Multiplex genome engineering using CRISPR/Cas systems

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

Gene targeting using zinc finger nucleases

A TALE nuclease architecture for efficient genome editing

Optical control of mammalian endogenous transcription and epigenetic states

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1060-1065

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scholarly article

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10.1038/NBT.3658

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10

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34

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2016-08-29T00:00:00Z

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1032294912

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27571369

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