CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.
about
Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signalingThe pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.Simian immunodeficiency virus and human immunodeficiency virus type 1 nef proteins show distinct patterns and mechanisms of Src kinase activation.Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking.Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like diseaseExpression of simian immunodeficiency virus nef in immune cells of transgenic mice leads to a severe AIDS-like disease.Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.Defective accessory genes in a human immunodeficiency virus type 1-infected long-term survivor lacking recoverable virusAltered cytokine expression in T lymphocytes from human immunodeficiency virus Tat transgenic miceMurine leukemia virus envelope protein in transgenic-mouse serum blocks infection in vitroImmunopathogenesis of oropharyngeal candidiasis in human immunodeficiency virus infection.Infectivity enhancement by human immunodeficiency virus type 1 Nef is independent of its association with a cellular serine/threonine kinaseThe human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.Adult AIDS-like disease in a novel inducible human immunodeficiency virus type 1 Nef transgenic mouse model: CD4+ T-cell activation is Nef dependent and can occur in the absence of lymphophenia.HIV-associated cellular senescence: A contributor to accelerated aging.Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry.Functional characterization of human immunodeficiency virus type 1 nef genes in patients with divergent rates of disease progression.Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus.Primary human immunodeficiency virus type 1 nef alleles show major differences in pathogenicity in transgenic mice.Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor NefT cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53.Selective expression of human immunodeficiency virus Nef in specific immune cell populations of transgenic mice is associated with distinct AIDS-like phenotypes.
P2860
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P2860
CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.
description
1993 nî lūn-bûn
@nan
1993 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
CD4 cell surface downregulatio ...... f intracellular sequestration.
@ast
CD4 cell surface downregulatio ...... f intracellular sequestration.
@en
CD4 cell surface downregulatio ...... f intracellular sequestration.
@nl
type
label
CD4 cell surface downregulatio ...... f intracellular sequestration.
@ast
CD4 cell surface downregulatio ...... f intracellular sequestration.
@en
CD4 cell surface downregulatio ...... f intracellular sequestration.
@nl
prefLabel
CD4 cell surface downregulatio ...... f intracellular sequestration.
@ast
CD4 cell surface downregulatio ...... f intracellular sequestration.
@en
CD4 cell surface downregulatio ...... f intracellular sequestration.
@nl
P2093
P2860
P1433
P1476
CD4 cell surface downregulatio ...... of intracellular sequestration
@en
P2093
Dzierzak EA
Pennington DJ
P2860
P304
P356
10.1002/J.1460-2075.1993.TB06186.X
P407
P577
1993-12-01T00:00:00Z