Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey.
about
From disease to treatment: from rare skeletal disorders to treatments for osteoporosisEmerging Therapies for OsteoporosisModulating Bone Resorption and Bone Formation in Opposite Directions in the Treatment of Postmenopausal OsteoporosisTherapeutic implications of suppressing osteoclast formation versus functionNovel advances in the treatment of osteoporosis.Odanacatib for the treatment of postmenopausal osteoporosis.Treatment of postmenopausal osteoporosis with odanacatib.[Cathepsin K antagonists: preclinical and clinical data].Antiresorptive drugs beyond bisphosphonates and selective oestrogen receptor modulators for the management of postmenopausal osteoporosisAntiresorptive effect of a cathepsin K inhibitor ONO-5334 and its relationship to BMD increase in a phase II trial for postmenopausal osteoporosis.Osteoclasts: more than 'bone eaters'.PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis.Bone mineral loss at the proximal femur in acute spinal cord injury.ONO-5334, a cathepsin K inhibitor, improves bone strength by preferentially increasing cortical bone mass in ovariectomized rats.Inhibition of cathepsin K increases modeling-based bone formation, and improves cortical dimension and strength in adult ovariectomized monkeys.Odanacatib treatment affects trabecular and cortical bone in the femur of postmenopausal women: results of a two-year placebo-controlled trial.A small molecule, odanacatib, inhibits inflammation and bone loss caused by endodontic disease.Odanacatib: a review of its potential in the management of osteoporosis in postmenopausal womenOPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism.Potential role of odanacatib in the treatment of osteoporosis.Odanacatib, A Cathepsin K-Specific Inhibitor, Inhibits Inflammation and Bone Loss Caused by Periodontal DiseasesOsteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formationProximal femoral density distribution and structure in relation to age and hip fracture risk in women.Odanacatib, a selective cathepsin K inhibitor to treat osteoporosis: safety, tolerability, pharmacokinetics and pharmacodynamics--results from single oral dose studies in healthy volunteers.Effects of odanacatib on bone matrix mineralization in rhesus monkeys are similar to those of alendronateTherapeutic inhibition of cathepsin K-reducing bone resorption while maintaining bone formation.Odanacatib in postmenopausal women with low bone mineral density: a review of current clinical evidence.Cathepsin K inhibitors increase distal femoral bone mineral density in rapidly growing rabbitsThe bone resorption inhibitors odanacatib and alendronate affect post-osteoclastic events differently in ovariectomized rabbitsBone modeling and remodeling: potential as therapeutic targets for the treatment of osteoporosis.Bone biology and anabolic therapies for bone: current status and future prospects.Inhibition of cathepsin K promotes osseointegration of titanium implants in ovariectomised ratsLong-term treatment with odanacatib maintains normal trabecular biomechanical properties in ovariectomized adult monkeys as demonstrated by micro-CT-based finite element analysis.Implications of osteoblast-osteoclast interactions in the management of osteoporosis by antiresorptive agents denosumab and odanacatib.Status of drug development for the prevention and treatment of osteoporosis.Emerging drugs for osteoporosis.Efficacy and safety of odanacatib treatment for patients with osteoporosis: a meta-analysis.Osteoporosis therapy: a novel insight from natural homeostatic system in the skeleton.Perspectives on osteoporosis therapies.Co-administration of antiresorptive and anabolic agents: a missed opportunity.
P2860
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P2860
Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey.
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Odanacatib treatment increases ...... ectomized adult rhesus monkey.
@ast
Odanacatib treatment increases ...... ectomized adult rhesus monkey.
@en
Odanacatib treatment increases ...... ectomized adult rhesus monkey.
@nl
type
label
Odanacatib treatment increases ...... ectomized adult rhesus monkey.
@ast
Odanacatib treatment increases ...... ectomized adult rhesus monkey.
@en
Odanacatib treatment increases ...... ectomized adult rhesus monkey.
@nl
prefLabel
Odanacatib treatment increases ...... ectomized adult rhesus monkey.
@ast
Odanacatib treatment increases ...... ectomized adult rhesus monkey.
@en
Odanacatib treatment increases ...... ectomized adult rhesus monkey.
@nl
P2093
P2860
P356
P1476
Odanacatib treatment increases ...... ectomized adult rhesus monkey.
@en
P2093
Boyd B Scott
Brenda L Pennypacker
Charles M Chen
Donald B Kimmel
Le T Duong
Maureen Pickarski
Tara Cusick
P2860
P304
P356
10.1002/JBMR.1477
P577
2012-03-01T00:00:00Z