Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.
about
Vimentin, colon cancer progression and resistance to butyrate and other HDACisWithaferin-A--A Natural Anticancer Agent with Pleitropic Mechanisms of ActionA Decade of Molecular Understanding of Withanolide Biosynthesis and In vitro Studies in Withania somnifera (L.) Dunal: Prospects and Perspectives for Pathway EngineeringEvasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transitionDifferential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidencesNADPH-cytochrome P450 reductase: molecular cloning and functional characterization of two paralogs from Withania somnifera (L.) dunalGolden berry-derived 4β-hydroxywithanolide E for selectively killing oral cancer cells by generating ROS, DNA damage, and apoptotic pathwaysWithaferin a alone and in combination with cisplatin suppresses growth and metastasis of ovarian cancer by targeting putative cancer stem cellsComparative transcriptome analysis of different chemotypes elucidates withanolide biosynthesis pathway from medicinal plant Withania somniferaIn vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index.Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma.Withaferin A inhibits experimental epithelial-mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors.Cloning and functional characterization of three branch point oxidosqualene cyclases from Withania somnifera (L.) dunal.Targeting Notch signaling pathway to overcome drug resistance for cancer therapyWithaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells.Withaferin A synergizes the therapeutic effect of doxorubicin through ROS-mediated autophagy in ovarian cancerWithaferin A Inhibits STAT3 and Induces Tumor Cell Death in Neuroblastoma and Multiple MyelomaTargeting Notch Signaling in Colorectal Cancer.Landomycins P-W, cytotoxic angucyclines from Streptomyces cyanogenus S-136Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approachOxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation.Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin ASynergistic cytotoxic action of cisplatin and withaferin A on ovarian cancer cell lines.Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activityγ-secretase inhibition combined with cisplatin enhances apoptosis of nasopharyngeal carcinoma cellsWithaferin A causes activation of Notch2 and Notch4 in human breast cancer cellsIdentification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemiaSilencing of sterol glycosyltransferases modulates the withanolide biosynthesis and leads to compromised basal immunity of Withania somniferaCytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways.Colon cancer progression is driven by APEX1-mediated upregulation of JaggedIn Silico Analysis of Microarray-Based Gene Expression Profiles Predicts Tumor Cell Response to WithanolidesRole of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells.Structure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells.Molecular targets and mechanisms of cancer prevention and treatment by withaferin a, a naturally occurring steroidal lactone.Novel withanolides target medullary thyroid cancer through inhibition of both RET phosphorylation and the mammalian target of rapamycin pathway.Natural withanolides: an overview.The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma.Withaferin-A Induces Apoptosis in Osteosarcoma U2OS Cell Line via Generation of ROS and Disruption of Mitochondrial Membrane Potential.Suppression of midkine gene promotes the antitumoral effect of cisplatin on human gastric cancer cell line AGS in vitro and in vivo via the modulation of Notch signaling pathway
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P2860
Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.
@ast
Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.
@en
Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.
@nl
type
label
Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.
@ast
Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.
@en
Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.
@nl
prefLabel
Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.
@ast
Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.
@en
Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.
@nl
P2093
P2860
P1476
Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.
@en
P2093
Chendil Damodaran
Mark B Evers
Sowmyalakshmi Srinivasan
Srinivas Koduru
P2860
P304
P356
10.1158/1535-7163.MCT-09-0771
P577
2010-01-06T00:00:00Z