mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. - Test2 - elhamkhani - TriplyDB

mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.

mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.

http://www.wikidata.org/entity/Q34098956

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Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling Down-regulation of Myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPaseold-35) in human melanoma cells Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence.Antimelanoma activity of the redox dye DCPIP (2,6-dichlorophenolindophenol) is antagonized by NQO1 Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action Mechanism of Action and Applications of Interleukin 24 in Immunotherapy Developing an effective gene therapy for prostate cancer: New technologies with potential to translate from the laboratory into the clinic DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma A novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosis Potential molecular mechanism for rodent tumorigenesis: mutational generation of Progression Elevated Gene-3 (PEG-3)Melanoma differentiation-associated gene-7, MDA-7/IL-24, selectively induces growth suppression, apoptosis in human hepatocellular carcinoma cell line HepG2 by replication-incompetent adenovirus vector.Recombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells.Replication-incompetent adenovirus vector-mediated MDA-7/IL-24 selectively induces growth suppression and apoptosis of hepatoma cell Line SMMC-7721.The p38 MAPK regulates IL-24 expression by stabilization of the 3' UTR of IL-24 mRNA.Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cells MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism.Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant glioma PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells The non-steroidal anti-inflammatory drugs Sulindac sulfide and Diclofenac induce apoptosis and differentiation in human acute myeloid leukemia cells through an AP-1 dependent pathway.Characterization of the canine mda-7 gene, transcripts and expression patterns.MDA-7/IL-24 as a cancer therapeutic: from bench to bedside.Dual cancer-specific targeting strategy cures primary and distant breast carcinomas in nude mice.Tumour suppressor function of MDA-7/IL-24 in human breast cancer Enhanced apoptosis-inducing function of MDA-7/IL-24 RGD mutant via the increased adhesion to tumor cells.IL-24 gene transfer sensitizes melanoma cells to erlotinib through modulation of the Apaf-1 and Akt signaling pathways.The development of MDA-7/IL-24 as a cancer therapeutic Recombinant adenovirus IL-24-Bax promotes apoptosis of hepatocellular carcinoma cells in vitro and in vivo.Melanoma differentiation associated gene-7/interleukin-24 potently induces apoptosis in human myeloid leukemia cells through a process regulated by endoplasmic reticulum stress.Secretable chaperone Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24 Enhancing mda-7/IL-24 therapy in renal carcinoma cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad.5/3 gene delivery A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels.Signaling-transduction pathways required for ex vivo expansion of human limbal explants on intact amniotic membrane.Enhanced prostate cancer gene transfer and therapy using a novel serotype chimera cancer terminator virus (Ad.5/3-CTV).IL-20: a new target for the treatment of inflammatory skin disease.Myeloid cells migrate in response to IL-24.Chapter One---Cancer terminator viruses and approaches for enhancing therapeutic outcomes.mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine JunD-mediated repression of GADD45α and γ regulates escape from cell death in prostate cancer

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mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.

http://www.wikidata.org/entity/Q34098956

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2002 nî lūn-bûn

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Proceedings of the National Academy of Sciences of the United States of America

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mda-7 (IL-24) Mediates selecti ...... of genes by means of p38 MAPK.

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Devanand Sarkar

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Irina V Lebedeva

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Kristoffer Valerie

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Moira Sauane

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Paul B Fisher

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Rahul V Gopalkrishnan

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Zao-Zhong Su

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P2860

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins

Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R

Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)

Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

Mammalian GADD34, an apoptosis- and DNA damage-inducible gene

Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth

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10054-10059

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10.1073/PNAS.152327199

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99

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