Development of allele-specific therapeutic siRNA in Meesmann epithelial corneal dystrophy.
about
Identification of presumed pathogenic KRT3 and KRT12 gene mutations associated with Meesmann corneal dystrophy.CRISPR/Cas9 DNA cleavage at SNP-derived PAM enables both in vitro and in vivo KRT12 mutation-specific targeting.Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy.Severe Meesmann's epithelial corneal dystrophy phenotype due to a missense mutation in the helix-initiation motif of keratin 12.Allele-specific silencing of EEC p63 mutant R304W restores p63 transcriptional activity.Allele dependent silencing of collagen type I using small interfering RNAs targeting 3'UTR Indels - a novel therapeutic approach in osteogenesis imperfecta.Keratins and disease at a glance.Allele-specific siRNA silencing for the common keratin 12 founder mutation in Meesmann epithelial corneal dystrophy.Autosomal-dominant Meesmann epithelial corneal dystrophy without an exon mutation in the keratin-3 or keratin-12 gene in a Chinese family.Towards personalised allele-specific CRISPR gene editing to treat autosomal dominant disorders.
P2860
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P2860
Development of allele-specific therapeutic siRNA in Meesmann epithelial corneal dystrophy.
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Development of allele-specific ...... epithelial corneal dystrophy.
@ast
Development of allele-specific ...... epithelial corneal dystrophy.
@en
Development of allele-specific ...... epithelial corneal dystrophy.
@nl
type
label
Development of allele-specific ...... epithelial corneal dystrophy.
@ast
Development of allele-specific ...... epithelial corneal dystrophy.
@en
Development of allele-specific ...... epithelial corneal dystrophy.
@nl
prefLabel
Development of allele-specific ...... epithelial corneal dystrophy.
@ast
Development of allele-specific ...... epithelial corneal dystrophy.
@en
Development of allele-specific ...... epithelial corneal dystrophy.
@nl
P2093
P2860
P1433
P1476
Development of allele-specific ...... epithelial corneal dystrophy.
@en
P2093
A Bethany Gibson
C B Tara Moore
Caroline J Macewen
Frances J D Smith
Haihui Liao
Jonathan E Moore
Kathryn H Weed
Laura D Corden
W H Irwin McLean
P2860
P304
P356
10.1371/JOURNAL.PONE.0028582
P407
P577
2011-12-12T00:00:00Z