Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo
about
Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling.Fibronectin expression modulates mammary epithelial cell proliferation during acinar differentiationIdentifying and targeting tumor-initiating cells in the treatment of breast cancerLung cancer cells that survive ionizing radiation show increased integrin α2β1- and EGFR-dependent invasivenessA computer-assisted 3D model for analyzing the aggregation of tumorigenic cells reveals specialized behaviors and unique cell types that facilitate aggregate coalescenceThe development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapyReceptor activator of NF-κB ligand induces cell adhesion and integrin α2 expression via NF-κB in head and neck cancers.The vascular basement membrane as "soil" in brain metastasisTension in CancerUnraveling the microenvironmental influences on the normal mammary gland and breast cancerControlled breast cancer microarrays for the deconvolution of cellular multilayering and density effects upon drug responsesHigh-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cellsBi-directional signaling: extracellular matrix and integrin regulation of breast tumor progressionWhy don't we get more cancer? A proposed role of the microenvironment in restraining cancer progressionIntegrins in cancer: biological implications and therapeutic opportunitiesOf extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer.Functional live-cell imaging demonstrates that beta1-integrin promotes type IV collagen degradation by breast and prostate cancer cellsExtracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging.Colorectal hyperplasia and dysplasia due to human carcinoembryonic antigen (CEA) family member expression in transgenic mice.Apical polarity in three-dimensional culture systems: where to now?Responsiveness to PI3K and MEK inhibitors in breast cancer. Use of a 3D culture system to study pathways related to hormone independence in mice.The microenvironment determines the breast cancer cells' phenotype: organization of MCF7 cells in 3D culturesMiniaturized pre-clinical cancer models as research and diagnostic tools.Role of β1-Integrin in Colorectal Cancer: Case-Control Study.BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cellsThe role of the focal adhesion protein PINCH1 for the radiosensitivity of adhesion and suspension cell culturesModelling molecular mechanisms of breast cancer and invasion: lessons from the normal glandDirecting the Self-assembly of Tumour Spheroids by Bioprinting Cellular Heterogeneous Models within Alginate/Gelatin HydrogelsBeta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1.Fibroblast heterogeneity in the cancer wound.C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin β1 glycosylation and activityInterstitial guidance of cancer invasion.Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109beta1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progressionBreast cancer cells in three-dimensional culture display an enhanced radioresponse after coordinate targeting of integrin alpha5beta1 and fibronectin.HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment.LMW-E/CDK2 deregulates acinar morphogenesis, induces tumorigenesis, and associates with the activated b-Raf-ERK1/2-mTOR pathway in breast cancer patientsGenome-wide gene expression analysis in cancer cells reveals 3D growth to affect ECM and processes associated with cell adhesion but not DNA repair.The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancerForce engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate.
P2860
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P2860
Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Beta1 integrin inhibitory anti ...... mensional cultures and in vivo
@ast
Beta1 integrin inhibitory anti ...... mensional cultures and in vivo
@en
Beta1 integrin inhibitory anti ...... mensional cultures and in vivo
@nl
type
label
Beta1 integrin inhibitory anti ...... mensional cultures and in vivo
@ast
Beta1 integrin inhibitory anti ...... mensional cultures and in vivo
@en
Beta1 integrin inhibitory anti ...... mensional cultures and in vivo
@nl
prefLabel
Beta1 integrin inhibitory anti ...... mensional cultures and in vivo
@ast
Beta1 integrin inhibitory anti ...... mensional cultures and in vivo
@en
Beta1 integrin inhibitory anti ...... mensional cultures and in vivo
@nl
P2093
P2860
P1433
P1476
Beta1 integrin inhibitory anti ...... mensional cultures and in vivo
@en
P2093
Catherine C Park
Chong J Park
Frederick Baehner
Joe W Gray
Maria Pallavicini
Mina J Bissell
P2860
P304
P356
10.1158/0008-5472.CAN-05-3071
P407
P577
2006-02-01T00:00:00Z