Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers - Test2 - elhamkhani - TriplyDB

Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

http://www.wikidata.org/entity/Q34153121

about

Comprehensive molecular portraits of human breast tumours PI3K/Akt/mTOR inhibitors in breast cancer Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer Phosphoinositides: tiny lipids with giant impact on cell regulation Phosphoinositides: Key modulators of energy metabolism Signaling by the phosphoinositide 3-kinase family in immune cells Role of the inositol polyphosphate-4-phosphatase type II Inpp4b in the generation of ovarian teratomas Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases SHIP2 multiple functions: a balance between a negative control of PtdIns(3,4,5)P₃ level, a positive control of PtdIns(3,4)P₂ production, and intrinsic docking properties.PI3K pathway activation in high-grade ductal carcinoma in situ--implications for progression to invasive breast carcinoma.PI(3,4)P2 plays critical roles in the regulation of focal adhesion dynamics of MDA-MB-231 breast cancer cells Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition.Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes.Epigenetic inactivation of inositol polyphosphate 4-phosphatase B (INPP4B), a regulator of PI3K/AKT signaling pathway in EBV-associated nasopharyngeal carcinoma INPP4B: the new kid on the PI3K block.PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control Genetically engineered mouse models of PI3K signaling in breast cancer.Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo.Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities Integrative investigation on breast cancer in ER, PR and HER2-defined subgroups using mRNA and miRNA expression profiling.Microarray phosphatome profiling of breast cancer patients unveils a complex phosphatase regulatory role of the MAPK and PI3K pathways in estrogen receptor-negative breast cancers Linking signaling pathways to transcriptional programs in breast cancer.Micro-scale genomic DNA copy number aberrations as another means of mutagenesis in breast cancer.SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer An integrative analysis of PIK3CA mutation, PTEN, and INPP4B expression in terms of trastuzumab efficacy in HER2-positive breast cancer Metformin and erlotinib synergize to inhibit basal breast cancer.Discovery and development of small molecule SHIP phosphatase modulators.PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.Phosphatases: the new brakes for cancer development?An ShRNA Based Genetic Screen Identified Sesn2 as a Potential Tumor Suppressor in Lung Cancer via Suppression of Akt-mTOR-p70S6K Signaling Elevated PI3K signaling drives multiple breast cancer subtypes.Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells.Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.INPP4B Is a Tumor Suppressor in the Context of PTEN Deficiency.Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer.Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases.Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival.Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer A novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples

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P2860

Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

http://www.wikidata.org/entity/Q34153121

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers

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Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers

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Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers

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type

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Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers

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Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers

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Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers

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Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers

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Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers

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Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers

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PNAS.1015245107

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Proceedings of the National Academy of Sciences of the United States of America

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Inositol polyphosphate 4-phosp ...... uman basal-like breast cancers

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Absorn Sriratana

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Benjamin J Shields

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Jessica Vieusseux

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John E J Rasko

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Laura Baglietto

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Miriel Ho

http://www.w3.org/2001/XMLSchema#string

Philip W Majerus

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Rajendra Gurung

http://www.w3.org/2001/XMLSchema#string

Robert L Sutherland

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Sandra A O'Toole

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P2860

The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family

The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol

Somatic mutation and gain of copy number of PIK3CA in human breast cancer.

High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

Repeated observation of breast tumor subtypes in independent gene expression data sets

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

ONCOMINE: a cancer microarray database and integrated data-mining platform

A genetic screen for candidate tumor suppressors identifies REST

Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype

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22231-22236

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scholarly article

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10.1073/PNAS.1015245107

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51

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107

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Graham G. Giles

Charles G. Bailey

Christina A. Mitchell

Elena López-Knowles

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2010-12-02T00:00:00Z

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49654179

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21127264

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