Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.
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An efficient synthesis of novel pyrano[2,3-d]- and furopyrano[2,3-d]pyrimidines via indium-catalyzed multi-component domino reactionAn Odyssey in antiviral drug development-50 years at the Rega Institute: 1964-2014Approved Antiviral Drugs over the Past 50 YearsDirect comparisons of inhibitor sensitivities of reverse transcriptases from feline and human immunodeficiency virusesInhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesisRibavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitroSynthesis of a nucleoside bioconjugate system as a potential anti-HIV agentAnalysis and prediction of highly effective antiviral peptides based on random forestsHigh performance liquid chromatography analysis of 9-(2',3'-dideoxy-2'beta-fluoro-D-threo-penta furanosyl) adenine and its metabolite in human plasma using solid-phase extraction on a polyfluorinated reversed stationary phase.Features of Maternal HIV-1 Associated with Lack of Vertical TransmissionTreatment of human immunodeficiency virus infectionsAnti-human immunodeficiency virus type 1 activity and resistance profile of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine in vitroAzidothymidine: crystal structure and possible functional role of the azido group.Population pharmacokinetics of stavudine (d4T) in patients with AIDS or advanced AIDS-related complexMutants of feline immunodeficiency virus resistant to 2',3'-dideoxy-2',3'-didehydrothymidine.Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rhesus monkeys.Induction of the SOS response in Escherichia coli by azidothymidine and dideoxynucleosidesAntiviral therapy for human immunodeficiency virus infectionsKinetics and inhibition of reverse transcriptase from human and simian immunodeficiency viruses.Emerging anti-HIV drugs.Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rats.Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.Clinical significance of HIV reverse-transcriptase inhibitor-resistance mutations.Curious discoveries in antiviral drug development: the role of serendipity.Asymmetric synthesis and biological activity of L-bicyclocarba-d4T.Design, enantiopure synthesis, and biological evaluation of novel iso-D-2',3'-dideoxy-3'-fluorothianucleoside derivatives as a bioisostere of lamivudine.Synthesis and antiviral activity of apio dideoxy nucleosides with azido or amino substituent.Efficacy of antiviral chemotherapy for retrovirus-infected cats: What does the current literature tell us?Synthesis and anticancer activity of some novel fused pyridine ring system.Synthesis of novel acyclic nucleoside analogues with anti-retroviral activity.Effects of drugs on 2',3'-dideoxy-2',3'-didehydrothymidine phosphorylation in vitro.In vitro drug combination of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil with anti-human immunodeficiency virus or anticancer nucleosides.Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile (2nd edition): retroviruses and hepadnaviruses.Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus.SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells.Pd(OAc)2-catalyzed dehydrogenative C-H activation: An expedient synthesis of uracil-annulated β-carbolinones.Isothiazole derivatives as novel HIV replication inhibitors.Bis-ketol nucleoside triesters as prodrugs of the antiviral nucleoside triphosphate analogues of 3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine.Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase.Imidazo[1,5-b]pyridazine-d4T conjugates: synthesis and anti-human immunodeficiency virus evaluation.
P2860
Q21198743-05231CF9-6BFD-4F68-9982-2D2FA1B9CE3CQ26771734-4393933E-FC2E-4B99-9F96-5441720821F8Q27755387-FECC97CB-6C00-4794-B304-563D082DA1D7Q28323510-87C1A569-F396-4154-87CE-477AE7ED9154Q28335579-B04E1FB4-2E02-4789-98B0-B71511E43C15Q28361577-331B1FD8-1433-4788-9817-FB0DC32DBDA1Q28370032-0CF9F197-08C0-489F-9B77-1315E3F15E2CQ28535105-084C4ADA-3941-475E-B578-8028D230B808Q30687083-A3F4D280-F53B-485A-B72F-ADE85676CA5FQ33555231-35C97CB9-9C79-4366-838C-F1144A1B219BQ33740357-89A31011-AA19-4057-8F4C-75A68F19480CQ33938098-117F100D-A604-4928-98C6-45485B3568EDQ34368600-73DA381F-6DA5-44E8-9D74-D9B89065453AQ35119768-D0EA15CA-40FA-41E4-8E4D-5DDB42C2269FQ35126454-97B4DC9F-5DA0-4F4E-B46D-FDEC0B311A06Q35262604-521152D4-8806-45FD-97B9-9B640D62739AQ35263031-E1211D6A-DCBE-468A-9F08-B996886EF457Q35366050-820702B2-E601-4994-9BEC-6DC0EC879A3BQ35566030-A4AF86E8-A1C4-457E-B20D-1893AB60102FQ36150601-AB8B4F39-BA94-4F22-A58B-B96DBFC2C8EEQ36753413-F6C89652-8A48-44FE-B75C-0C316691DACEQ37409900-B21007B8-967C-49B2-86E4-FE7208A3CE3FQ37859395-CBDBBEDB-6319-4154-B4EA-4E1AD90821CDQ38366289-D5BA27B6-C1D4-4486-99B5-084BDCCD4BE3Q38503172-8F88AFFD-1EC7-4A96-B600-6AAA3E700469Q38503274-979D9DEA-7A37-4128-9B05-745A76CFDEE4Q38528890-38EC2087-00DD-43A5-BE8E-0FA969CF0ADEQ38612672-E55EE0DC-6912-4DBE-A33B-B9BB0D98D9C0Q39232196-7590D075-87E7-4E71-A55D-43CA4602BFABQ39667999-C13EC2DA-F77F-48C0-85C5-01BDE73BDCF3Q39784283-50950008-428A-40EA-8BD7-CDAE45BCC34BQ39871056-344EB78C-BBB9-44B3-97F5-11577F3B980BQ40055204-1DDFFE88-5D33-46F4-ADFF-6C480BA46A8EQ40283999-2F78D901-CD48-4FA9-BD55-D8CAC43ADDD1Q40324306-A700D064-9E33-40CD-9FF5-C2ED33D555ACQ40479529-398ED8ED-EFBB-45C9-8CDF-28A405F879EDQ40509090-73FE4575-78D5-4DEB-B46B-93545C1681ADQ40562095-2F0D3B41-853A-4541-B3AD-F178C14C7F19Q40975672-600A7F42-5B36-4BE0-B950-A1F5D121F261Q40983879-DF7951F0-C600-4832-AD56-8146ED0055E6
P2860
Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.
description
1987 nî lūn-bûn
@nan
1987 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
Both 2',3'-dideoxythymidine an ...... cy virus replication in vitro.
@ast
Both 2',3'-dideoxythymidine an ...... cy virus replication in vitro.
@en
Both 2',3'-dideoxythymidine an ...... cy virus replication in vitro.
@nl
type
label
Both 2',3'-dideoxythymidine an ...... cy virus replication in vitro.
@ast
Both 2',3'-dideoxythymidine an ...... cy virus replication in vitro.
@en
Both 2',3'-dideoxythymidine an ...... cy virus replication in vitro.
@nl
prefLabel
Both 2',3'-dideoxythymidine an ...... cy virus replication in vitro.
@ast
Both 2',3'-dideoxythymidine an ...... cy virus replication in vitro.
@en
Both 2',3'-dideoxythymidine an ...... cy virus replication in vitro.
@nl
P2093
P1476
Both 2',3'-dideoxythymidine an ...... ncy virus replication in vitro
@en
P2093
P304
P356
10.1016/0006-291X(87)90460-8
P407
P577
1987-01-01T00:00:00Z