The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells.
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Mebendazole reduces vascular smooth muscle cell proliferation and neointimal formation following vascular injury in miceRepositioning approved drugs for the treatment of problematic cancers using a screening approach.Chemical dissection of the cell cycle: probes for cell biology and anti-cancer drug development.Identification of a novel synthetic thiazolidin compound capable of inducing c-Jun NH2-terminal kinase-dependent apoptosis in human colon cancer cells.Potent inhibition of tumoral hypoxia-inducible factor 1alpha by albendazole.A novel synthetic analog of 5, 8-disubstituted quinazolines blocks mitosis and induces apoptosis of tumor cells by inhibiting microtubule polymerization.Repurposing Mebendazole as a Replacement for Vincristine for the Treatment of Brain Tumors.Alpha-santalol, a chemopreventive agent against skin cancer, causes G2/M cell cycle arrest in both p53-mutated human epidermoid carcinoma A431 cells and p53 wild-type human melanoma UACC-62 cells.Repurposing Drugs in Oncology (ReDO)-mebendazole as an anti-cancer agentJNK1-dependent antimitotic activity of thiazolidin compounds in human non-small-cell lung and colon cancer cells.Repurposing the antihelmintic mebendazole as a hedgehog inhibitor.Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme.Ethyl acetate extract from marine sponge Hyattella cribriformis exhibit potent anticancer activity by promoting tubulin polymerization as evidenced mitotic arrest and induction of apoptosis.Anti-Neoplastic Cytotoxicity of Gemcitabine-(C4-amide)-[anti-EGFR] in Dual-combination with Epirubicin-(C3-amide)-[anti-HER2/neu] against Chemotherapeutic-Resistant Mammary Adenocarcinoma (SKBr-3) and the Complementary Effect of Mebendazole.Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis.Influence of Alternative Tubulin Inhibitors on the Potency of a Epirubicin-Immunochemotherapeutic Synthesized with an Ultra Violet Light-Activated Intermediate: Influence of incorporating an internal/integral disulfide bond structure and AlternativeDrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing.Impairment of the ubiquitin-proteasome pathway by methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate leads to a potent cytotoxic effect in tumor cells: a novel antiproliferative agent with a potential therapeutic implication.Anthelmintic mebendazole enhances cisplatin's effect on suppressing cell proliferation and promotes differentiation of head and neck squamous cell carcinoma (HNSCC).Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical modelAntihelminthic benzimidazoles potentiate navitoclax (ABT-263) activity by inducing Noxa-dependent apoptosis in non-small cell lung cancer (NSCLC) cell lines.Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen.The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanomaEffect of squalane on mebendazole-loaded Compritol® nanoparticles.Gemcitabine-(C4-amide)-[anti-HER2/neu] Anti-Neoplastic Cytotoxicity in Dual Combination with Mebendazole against Chemotherapeutic-Resistant Mammary Adenocarcinoma.Comprehensive Modeling and Discovery of Mebendazole as a Novel TRAF2- and NCK-interacting Kinase InhibitorQuantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.RepurposeVS: A Drug Repurposing-Focused Computational Method for Accurate Drug-Target Signature Predictions.Online structure-based screening of purchasable approved drugs and natural compounds: retrospective examples of drug repositioning on cancer targets
P2860
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P2860
The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells.
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The anthelmintic drug mebendaz ...... -small cell lung cancer cells.
@ast
The anthelmintic drug mebendaz ...... -small cell lung cancer cells.
@en
The anthelmintic drug mebendaz ...... -small cell lung cancer cells.
@nl
type
label
The anthelmintic drug mebendaz ...... -small cell lung cancer cells.
@ast
The anthelmintic drug mebendaz ...... -small cell lung cancer cells.
@en
The anthelmintic drug mebendaz ...... -small cell lung cancer cells.
@nl
prefLabel
The anthelmintic drug mebendaz ...... -small cell lung cancer cells.
@ast
The anthelmintic drug mebendaz ...... -small cell lung cancer cells.
@en
The anthelmintic drug mebendaz ...... -small cell lung cancer cells.
@nl
P2093
P1476
The anthelmintic drug mebendaz ...... -small cell lung cancer cells.
@en
P2093
Jack A Roth
Ji-ichiro Sasaki
Rajagopal Ramesh
Sunil Chada
Tapas Mukhopadhyay
Yoshihito Gomyo
P304
P577
2002-11-01T00:00:00Z